Nature

Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein.

Stone, Mihalusova, O'connor, Prathapam, Collins, Zhuang; (JOURNAL ARTICLE)

Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.

Evans, von Hahn, Tscherne, Syder, Panis, Wölk, Hatziioannou, McKeating, Bieniasz, Rice; (JOURNAL ARTICLE)

Into the darkness.

Springel; (JOURNAL ARTICLE)

Research highlights.

none; (JOURNAL ARTICLE)

The structure of suspended graphene sheets.

Meyer, Geim, Katsnelson, Novoselov, Booth, Roth; (Journal Article, Research Support, Non-U.S. Gov't)

Data sharing: the next generation.

Butler; (News)

Physics: gravity passes a little test.

Speake; (News)

Bipolar supercurrent in graphene.

Heersche, Jarillo-Herrero, Oostinga, Vandersypen, Morpurgo; (Journal Article)

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.

Kawane, Ohtani, Miwa, Kizawa, Kanbara, Yoshioka, Yoshikawa, Nagata; (JOURNAL ARTICLE)

Radar satellites: mountains to molehills.

Schiermeier; (Journal Article)

A topographic map of recruitment in spinal cord.

McLean, Fan, Higashijima, Hale, Fetcho; (Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Genetically modified Plasmodium parasites as a protective experimental malaria vaccine.

Mueller, Labaied, Kappe, Matuschewski; (JOURNAL ARTICLE)

Relating ligand binding to activation gating in CNGA2 channels.

Biskup, Kusch, Schulz, Nache, Schwede, Lehmann, Hagen, Benndorf; (JOURNAL ARTICLE)

Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis.

Zaph, Troy, Taylor, Berman-Booty, Guild, Du, Yost, Gruber, May, Greten, Eckmann, Karin, Artis; (JOURNAL ARTICLE)

Letting the light in on Antarctic ecosystems.

Odling-Smee; (News)

Abstractions.

none; (JOURNAL ARTICLE)

Q&A: Ronald Plasterk interviewed by Alison Abbott.

Plasterk; (Interview)

Climate modelling: uncertainty in climate-sensitivity estimates.

Schneider; (Comment, Journal Article)

The roots of complex problems.

Gowers; (JOURNAL ARTICLE)

A single type of progenitor cell maintains normal epidermis.

Clayton, Doupé, Klein, Winton, Simons, Jones; (JOURNAL ARTICLE)

Implications for plastic flow in the deep mantle from modelling dislocations in MgSiO3 minerals.

Carrez, Ferré, Cordier; (Journal Article, Research Support, Non-U.S. Gov't)

Hippocampal remapping and grid realignment in entorhinal cortex.

Fyhn, Hafting, Treves, Moser, Moser; (JOURNAL ARTICLE)

Making the paper: Karen Liu.

none; (JOURNAL ARTICLE)

C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a.

Chen, Mirtsos, Suh, Lu, Lin, McKerlie, Lee, Baribault, Tian, Yeh; (JOURNAL ARTICLE)

Protecting biostructure.

McCann; (Journal Article)

Microscopy: atomic fingerprinting.

Shluger, Trevethan; (Comment, News)

Physiology: legacy of leaky channels.

Horn; (Comment, News)

New in Paperback.

none; (JOURNAL ARTICLE)

Artificial 'spin ice' in a geometrically frustrated lattice of nanoscale ferromagnetic islands.

Wang, Nisoli, Freitas, Li, McConville, Cooley, Lund, Samarth, Leighton, Crespi, Schiffer; (JOURNAL ARTICLE)

Climate modelling: Uncertainty in climate-sensitivity estimates (Reply).

Hegerl, Crowley, Hyde, Frame; (JOURNAL ARTICLE)

Sidelines.

none; (JOURNAL ARTICLE)

Meet the human metabolome.

Pearson; (News)

Science of hair: the roots of accomplishment.

Pearson; (News)

Cell biology: aneuploidy and cancer.

Pellman; (News)

A Mesozoic gliding mammal from northeastern China.

Meng, Hu, Wang, Wang, Li; (JOURNAL ARTICLE)

The molecular organization of cypovirus polyhedra.

Coulibaly, Chiu, Ikeda, Gutmann, Haebel, Schulze-Briese, Mori, Metcalf; (Journal Article, Research Support, Non-U.S. Gov't)

Need to distinguish science (good or bad) from ethics.

Campbell; (JOURNAL ARTICLE)

Key postdocs.

none; (JOURNAL ARTICLE)

Solid foundations.

none; (Editorial)

Transport and Anderson localization in disordered two-dimensional photonic lattices.

Schwartz, Bartal, Fishman, Segev; (Journal Article, Research Support, Non-U.S. Gov't)

Death toll in Iraq: survey team takes on its critics.

Giles; (News)

Photonics: light localized on the lattice.

Vardeny, Raikh; (Comment, News)

Fascinating rhythm.

Mehta; (JOURNAL ARTICLE)

Chemical identification of individual surface atoms by atomic force microscopy.

Sugimoto, Pou, Abe, Jelinek, Pérez, Morita, Custance; (Journal Article, Research Support, Non-U.S. Gov't)

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum.

Painter, Morrisey, Mather, Vaidya; (Journal Article, Research Support, N.I.H., Extramural)

The lab that asked the wrong questions.

Odling-Smee; (News)

Scientists rethink approach to HIV gels.

Check; (News)

Fish can infer social rank by observation alone.

Grosenick, Clement, Fernald; (JOURNAL ARTICLE)

Never mind the footprint, get the mass right.

Jarvis; (Comment, Letter)

Structure of an ABC transporter in complex with its binding protein.

Hollenstein, Frei, Locher; (JOURNAL ARTICLE)

Not saving the whale.

none; (Editorial)

50 & 100 Years Ago.

none; (JOURNAL ARTICLE)

Virology: holed up in a natural crystal.

Rey; (Comment, News)

Tyrosine kinase receptor RET is a key regulator of Peyer's Patch organogenesis.

Veiga-Fernandes, Coles, Foster, Patel, Williams, Natarajan, Barlow, Pachnis, Kioussis; (JOURNAL ARTICLE)

News in brief.

none; (JOURNAL ARTICLE)

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.

Glasson, Askew, Sheppard, Carito, Blanchet, Ma, Flannery, Peluso, Kanki, Yang, Majumdar, Morris; (JOURNAL ARTICLE)

Potential downsides of perfect pain relief.

Mannes, Iadarola; (Comment, Letter)

Trial and failure.

none; (Editorial)

A merger too far?

Wadman; (Journal Article)

Trio of studies makes headway in HIV battle.

Check; (News)

Gating pore current in an inherited ion channelopathy.

Sokolov, Scheuer, Catterall; (Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Materials science: flaky research.

Venema; (Comment, News)

Laser physics: extreme light.

Gerstner; (News)


Science

Zoology. African penguin populations reported in a puzzling decline.

Koenig; (News)

Electrical activity during the 2006 Mount St. Augustine volcanic eruptions.

Thomas, Krehbiel, Rison, Edens, Aulich, Winn, McNutt, Tytgat, Clark; (Journal Article)

Atmosphere. Forecasting hurricane intensity and impacts.

Willoughby; (Comment, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

CREB-Binding Protein Modulates Repeat Instability in a Drosophila Model for PolyQ Disease.

Jung, Bonini; (JOURNAL ARTICLE)

Archaeology. Mystery towers in Peru are an ancient solar calendar.

Mann; (Comment, Journal Article)

Nicola Clayton profile. Nicky and the jays.

Morell; (News)

Hurricane intensity and eyewall replacement.

Houze, Chen, Smull, Lee, Bell; (Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Cancer research. Tight budget takes a toll on U.S.-funded clinical trials.

Couzin; (News)

U.S. Department of Agriculture. Farm bill may contain seeds for more robust research.

Stokstad; (News)

Neuroanatomy. Brain evolution studies go micro.

Balter; (News)

Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation.

Mayr, Hemann, Bartel; (JOURNAL ARTICLE)

Oceans. Climate drives sea change.

Greene, Pershing; (Journal Article)

Oncology. Recruiting the cell's own guardian for cancer therapy.

Marx; (News)

The focusing of electron flow and a Veselago lens in graphene p-n junctions.

Cheianov, Fal'ko, Altshuler; (Journal Article, Research Support, Non-U.S. Gov't)

Local interactions select for lower pathogen infectivity.

Boots, Mealor; (Journal Article, Research Support, Non-U.S. Gov't)

Halwaxiids and the early evolution of the lophotrochozoans.

Morris, Caron; (Journal Article, Research Support, Non-U.S. Gov't)

Predictions of the properties of water from first principles.

Bukowski, Szalewicz, Groenenboom, van der Avoird; (Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity.

Tenoever, Ng, Chua, McWhirter, García-Sastre, Maniatis; (Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Ecology. How the wood moves.

Shea; (Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chankillo: a 2300-year-old solar observatory in coastal Peru.

Ghezzi, Ruggles; (Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Nuclear war. Consequences of regional-scale nuclear conflicts.

Toon, Robock, Turco, Bardeen, Oman, Stenchikov; (Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Recognizing William Bateson's contributions.

Schwartz; (Comment, Letter)

Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.

Dalley, Fryer, Brichard, Robinson, Theobald, Lääne, Peña, Murphy, Shah, Probst, Abakumova, Aigbirhio, Richards, Hong, Baron, Everitt, Robbins; (Journal Article, Research Support, Non-U.S. Gov't)

Animal health research.

Zinsstag; (Editorial)

Astronomy. Nebulae around evolved stars.

Soker; (Comment, Journal Article)

Reconstitution of DNA segregation driven by assembly of a prokaryotic actin homolog.

Garner, Campbell, Weibel, Mullins; (Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

A way to deal with image enhancement.

Bodenstein; (Comment, News)

Gene body-specific methylation on the active X chromosome.

Hellman, Chess; (Journal Article, Research Support, N.I.H., Extramural)

Assessment. Standardized tests predict graduate students' success.

Kuncel, Hezlett; (Journal Article)

Redefining the age of Clovis: implications for the peopling of the Americas.

Waters, Stafford; (Journal Article, Research Support, Non-U.S. Gov't)

Comment on "Detecting awareness in the vegetative state".

Nachev, Husain; (Comment, Journal Article, Research Support, Non-U.S. Gov't)

Microbiology. Mayhem in the lung.

Kahl, Peters; (Comment, Journal Article)

Chemistry. Charge flipping and beyond.

Gies; (Comment, Journal Article)

Biodiversity. Reconstructing Brazil's Atlantic rainforest.

Wuethrich; (News)

Mathematics. Quasi-crystal conundrum opens a tiling can of worms.

Bohannon; (Comment, News)

Physics. Negative refraction for electrons?

Pendry; (Comment, Journal Article)

Skin biology. A healthy tan?

Wickelgren; (News)

Redirection of silencing targets by adenosine-to-inosine editing of miRNAs.

Kawahara, Zinshteyn, Sethupathy, Iizasa, Hatzigeorgiou, Nishikura; (Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Stem cells. Data on Adult stem cells questioned.

Holden; (Journal Article)

Effect of Sedimentation on Ice-Sheet Grounding-Line Stability.

Alley, Anandakrishnan, Dupont, Parizek, Pollard; (JOURNAL ARTICLE)

Scientific publishing. European Union steps back from open-access leap.

Enserink; (News)

Rethinking organic aerosols: semivolatile emissions and photochemical aging.

Robinson, Donahue, Shrivastava, Weitkamp, Sage, Grieshop, Lane, Pierce, Pandis; (Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Online versus hardcopy textbooks.

Dorn; (Letter)

Discovery of Till Deposition at the Grounding Line of Whillans Ice Stream.

Anandakrishnan, Catania, Alley, Horgan; (JOURNAL ARTICLE)

Epidemiology. Keep it local.

Buckling; (Comment, Journal Article)

Shaping of elastic sheets by prescription of non-Euclidean metrics.

Klein, Efrati, Sharon; (Journal Article, Research Support, Non-U.S. Gov't)

Decagonal and quasi-crystalline tilings in medieval Islamic architecture.

Lu, Steinhardt; (Journal Article, Research Support, Non-U.S. Gov't)

Biochemistry. A missing link in membrane protein evolution.

Poolman, Geertsma, Slotboom; (Comment, Journal Article, Research Support, Non-U.S. Gov't)

Chemistry. Water from first principles.

Stone; (Comment, Journal Article)

U.S. 2007 budget. NSF enjoys a heartfelt ending to a difficult budget year.

Mervis; (News)

Science, information, and power.

Kennedy; (Editorial)

Particle physics. Dreams collide with reality for international experiment.

Cho; (News)

Was there really an Archean phosphate crisis?

Konhauser, Lalonde, Amskold, Holland; (Journal Article, Research Support, Non-U.S. Gov't)

U.S. innovation. Democrats rescue technology research program.

Kintisch; (News)

Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit.

Lamsa, Heeroma, Somogyi, Rusakov, Kullmann; (Journal Article, Research Support, Non-U.S. Gov't)

Comment on "Detecting awareness in the vegetative state".

Greenberg; (Comment, Journal Article)

The triple-ring nebula around SN 1987A: fingerprint of a binary merger.

Morris, Podsiadlowski; (Journal Article)

Plant science. Nibbling at the plant cell nucleus.

Dangl; (Comment, Journal Article)

Climate change. Pollutant hazes extend their climate-changing reach.

Kerr; (News)

Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses.

Chang, Palanivel, Kinjyo, Schambach, Intlekofer, Banerjee, Longworth, Vinup, Mrass, Oliaro, Killeen, Orange, Russell, Weninger, Reiner; (JOURNAL ARTICLE)

Structure of the polycrystalline zeolite catalyst IM-5 solved by enhanced charge flipping.

Baerlocher, Gramm, Massüger, McCusker, He, Hovmöller, Zou; (Journal Article, Research Support, Non-U.S. Gov't)

LRP6 mutation in a family with early coronary disease and metabolic risk factors.

Mani, Radhakrishnan, Wang, Mani, Mani, Nelson-Williams, Carew, Mane, Najmabadi, Wu, Lifton; (Journal Article, Research Support, N.I.H., Extramural)

A route to the brightest possible neutron source?

Taylor, Dunne, Bennington, Ansell, Gardner, Norreys, Broome, Findlay, Nelmes; (Journal Article)

Focusing beyond the diffraction limit with far-field time reversal.

Lerosey, de Rosny, Tourin, Fink; (Journal Article, Research Support, Non-U.S. Gov't)

Skin biology. Why I have red hair, need to avoid the sun, and shouldn't commit a crime.

Wickelgren; (News)

Primate behavior. Spear-wielding chimps seen hunting bush babies.

Gibbons; (News)

Environmental regulation. U.S. courts say transgenic crops need tighter scrutiny.

Charles; (News)

Is the EC afraid of its own visions?

Settele, Kühn, Klotz, Hammen, Spangenberg; (Letter)

Developing drugs for tuberculosis.

Farlow; (Comment, Letter)

AAAS annual meeting. Wedging sustainability into public consciousness.

Coontz; (News)

Materials science. Better geometry through chemistry.

Kamien; (Comment, Journal Article)

Imaging of Single Organic Molecules in Motion.

Koshino, Tanaka, Solin, Suenaga, Isobe, Nakamura; (JOURNAL ARTICLE)

To sleep, perchance to dream.

Conduit; (Comment, Letter)

Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication.

Triboulet, Mari, Lin, Chable-Bessia, Bennasser, Lebrigand, Cardinaud, Maurin, Barbry, Baillat, Reynes, Corbeau, Jeang, Benkirane; (JOURNAL ARTICLE)

A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in Drosophila.

Gunawardane, Saito, Nishida, Miyoshi, Kawamura, Nagami, Siomi, Siomi; (JOURNAL ARTICLE)

Archaeology. Clovis technology flowered briefly and late, dates suggest.

Mann; (Comment, News)


Nature Methods

Ribosome display: selecting and evolving proteins in vitro that specifically bind to a target.

Zahnd, Amstutz, Plückthun; (Journal Article)

Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.

Elias, Gygi; (Journal Article)

FRETting for a more detailed interactome.

Kaganman; (Journal Article)

Primer-site SNPs mask mutations.

Quinlan, Marth; (Journal Article)

The development of a bioengineered organ germ method.

Nakao, Morita, Saji, Ishida, Tomita, Ogawa, Saitoh, Tomooka, Tsuji; (Journal Article)

Imaging receptor microdomains on leukocyte subsets in live mice.

Chiang, Hidalgo, Chang, Frenette; (Journal Article)

Tinkering with the fly genome.

Potash; (Journal Article)

The unnatural culture of amino acids.

Hausmann, Ling, Ibba; (Journal Article)

Cartography of an organelle.

de Souza; (Journal Article)

Controlling proteins the intein way.

Evanko; (Journal Article)

Taking on chromatography's hard cases.

Dove; (Journal Article)

Same computational analysis, different miRNA target predictions.

Hatzigeorgiou; (Journal Article)

Rapid SNP diagnostics using asymmetric isothermal amplification and a new mismatch-suppression technology.

Mitani, Lezhava, Kawai, Kikuchi, Oguchi-Katayama, Kogo, Itoh, Miyagi, Takakura, Hoshi, Kato, Arakawa, Shibata, Fukui, Masui, Kuramitsu, Kiyotani, Chalk, Tsunekawa, Murakami, Kamataki, Oka, Shimada, Cizdziel, Hayashizaki; (JOURNAL ARTICLE)

Eukaryotic ribosome display with in situ DNA recovery.

He, Taussig; (Journal Article)

Nanofabricated quartz cylinders for angular trapping: DNA supercoiling torque detection.

Deufel, Forth, Simmons, Dejgosha, Wang; (Journal Article)

Happy to take questions.

none; (Editorial)

Same computational analysis, different miRNA target predictions.

Xu; (Journal Article)

Ultrafast spectroscopy: timing is everything.

Doerr; (Journal Article)

Genetic incorporation of unnatural amino acids into proteins in mammalian cells.

Liu, Brock, Chen, Chen, Schultz; (Journal Article)


Nature Biotechnology

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.

Wang, Au, Chen, Shao, Daheron, Bai, Arzigian, Fukumura, Jain, Scadden; (JOURNAL ARTICLE)

An integrated mass spectrometric and computational framework for the analysis of protein interaction networks.

Rinner, Mueller, Hubálek, Müller, Gstaiger, Aebersold; (JOURNAL ARTICLE)

Female-specific insect lethality engineered using alternative splicing.

Fu, Condon, Epton, Gong, Jin, Condon, Morrison, Dafa'alla, Alphey; (JOURNAL ARTICLE)

Improving catalytic function by ProSAR-driven enzyme evolution.

Fox, Davis, Mundorff, Newman, Gavrilovic, Ma, Chung, Ching, Tam, Muley, Grate, Gruber, Whitman, Sheldon, Huisman; (JOURNAL ARTICLE)


Nature Medicine

In vivo imaging of siRNA delivery and silencing in tumors.

Medarova, Pham, Farrar, Petkova, Moore; (JOURNAL ARTICLE)

beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.

Brunham, Kruit, Pape, Timmins, Reuwer, Vasanji, Marsh, Rodrigues, Johnson, Parks, Verchere, Hayden; (JOURNAL ARTICLE)

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3beta activity.

Trivedi, Luo, Yin, Zhang, Zhu, Wang, Floss, Goettlicher, Noppinger, Wurst, Ferrari, Abrams, Gruber, Epstein; (JOURNAL ARTICLE)

Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure.

Lymperopoulos, Rengo, Funakoshi, Eckhart, Koch; (JOURNAL ARTICLE)

Humanization of autoantigen.

Nishie, Sawamura, Goto, Ito, Shibaki, McMillan, Sakai, Nakamura, Olasz, Yancey, Akiyama, Shimizu; (JOURNAL ARTICLE)


Nature Genetics

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells.

Chen, Hevi, Gay, Tsujimoto, He, Zhang, Ueda, Li; (Journal Article)

Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning.

Yang, Smith, Tian, Lewin, Renard, Wakayama; (Journal Article)

A genome-wide analysis in Saccharomyces cerevisiae demonstrates the influence of chromatin modifiers on transcription.

Steinfeld, Shamir, Kupiec; (Journal Article)

Nephrogenetics on world kidney day.

none; (Journal Article)

Mapping autism risk loci using genetic linkage and chromosomal rearrangements.

Szatmari, Paterson, Zwaigenbaum, Roberts, Brian, Liu, Vincent, Skaug, Thompson, Senman, Feuk, Qian, Bryson, Jones, Marshall, Scherer, Vieland, Bartlett, Mangin, Goedken, Segre, Pericak-Vance, Cuccaro, Gilbert, Wright, Abramson, Betancur, Bourgeron, Gillberg, Leboyer, Buxbaum, Davis, Hollander, Silverman, Hallmayer, Lotspeich, Sutcliffe, Haines, Folstein, Piven, Wassink, Sheffield, Geschwind, Bucan, Brown, Cantor, Constantino, Gilliam, Herbert, Lajonchere, Ledbetter, Lese-Martin, Miller, Nelson, Samango-Sprouse, Spence, State, Tanzi, Coon, Dawson, Devlin, Estes, Flodman, Klei, McMahon, Minshew, Munson, Korvatska, Rodier, Schellenberg, Smith, Spence, Stodgell, Tepper, Wijsman, Yu, Rogé, Mantoulan, Wittemeyer, Poustka, Felder, Klauck, Schuster, Poustka, Bölte, Feineis-Matthews, Herbrecht, Schmötzer, Tsiantis, Papanikolaou, Maestrini, Bacchelli, Blasi, Carone, Toma, Van Engeland, de Jonge, Kemner, Koop, Langemeijer, Hijimans, Staal, Baird, Bolton, Rutter, Weisblatt, Green, Aldred, Wilkinson, Pickles, Le Couteur, Berney, McConachie, Bailey, Francis, Honeyman, Hutchinson, Parr, Wallace, Monaco, Barnby, Kobayashi, Lamb, Sousa, Sykes, Cook, Guter, Leventhal, Salt, Lord, Corsello, Hus, Weeks, Volkmar, Tauber, Fombonne, Shih; (Journal Article)

Shaping specificity in signaling networks.

Albert, Oltvai; (Journal Article)

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.

Khor, Chapman, Vannberg, Dunne, Murphy, Ling, Frodsham, Walley, Kyrieleis, Khan, Aucan, Segal, Moore, Knox, Campbell, Lienhardt, Scott, Aaby, Sow, Grignani, Sillah, Sirugo, Peshu, Williams, Maitland, Davies, Kwiatkowski, Day, Yala, Crook, Marsh, Berkley, O'neill, Hill; (JOURNAL ARTICLE)

The devil is in the DNA.

Chanock, Thomas; (JOURNAL ARTICLE)

CORRIGENDUM: Genome variation and evolution of the malaria parasite Plasmodium falciparum.

Jeffares, Pain, Berry, Cox, Stalker, Ingle, Thomas, Quail, Siebenthall, Uhlemann, Kyes, Krishna, Newbold, Dermitzakis, Berriman; (Journal Article)

Think globally, act locally.

Reinke; (Journal Article)

On the parsing of statistical information in family-based association testing.

McQueen, Weiss, Laird, Lange; (Journal Article)

Research highlights.

none; (Journal Article)

Reply to "STOX1 is not imprinted and is not likely to be involved in preeclampsia".

van Dijk, van Bezu, Chim, Lo, Blankenstein, Oudejans; (Journal Article)

Touching base.

none; (Journal Article)

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.

Romeo, Pennacchio, Fu, Boerwinkle, Tybjaerg-Hansen, Hobbs, Cohen; (JOURNAL ARTICLE)

Enhancing genome annotation with chromatin.

Schübeler; (Journal Article)

Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum.

Stevanin, Santorelli, Azzedine, Coutinho, Chomilier, Denora, Martin, Ouvrard-Hernandez, Tessa, Bouslam, Lossos, Charles, Loureiro, Elleuch, Confavreux, Cruz, Ruberg, Leguern, Grid, Tazir, Fontaine, Filla, Bertini, Durr, Brice; (JOURNAL ARTICLE)

STOX1 is not imprinted and is not likely to be involved in preeclampsia.

Iglesias-Platas, Monk, Jebbink, Buimer, Boer, van der Post, Hills, Apostolidou, Ris-Stalpers, Stanier, Moore; (Journal Article)

A module of negative feedback regulators defines growth factor signaling.

Amit, Citri, Shay, Lu, Katz, Zhang, Tarcic, Siwak, Lahad, Jacob-Hirsch, Amariglio, Vaisman, Segal, Rechavi, Alon, Mills, Domany, Yarden; (JOURNAL ARTICLE)

Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.

Bowman, Lam, Jafar-Nejad, Chen, Richman, Samaco, Fryer, Kahle, Orr, Zoghbi; (JOURNAL ARTICLE)

Epistatic buffering of fitness loss in yeast double deletion strains.

Jasnos, Korona; (JOURNAL ARTICLE)

DNMT1 knockout delivers a strong blow to genome stability and cell viability.

Brown, Robertson; (Journal Article)


Molecular Medicine


Proteomics


Nature Drug Discovery


BMC Bioinformatics

Blast sampling for structural and functional analyses.

Friedrich, Ripp, Garnier, Bettler, Deleage, Poch, Moulinier; (JOURNAL ARTICLE)

Inference of miRNA targets using evolutionary conservation and pathway analysis.

Gaidatzis, van Nimwegen, Hausser, Zavolan; (JOURNAL ARTICLE)

Phylo-mLogo: an interactive and hierarchical multiple-logo visualization tool for alignment of many sequences.

Shih, Lee, Peng, Wu; (Journal Article, Research Support, Non-U.S. Gov't)

Factor analysis for gene regulatory networks and transcription factor activity profiles.

Pournara, Wernisch; (JOURNAL ARTICLE)

AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides.

Conchillo-Sole, de Groot, Aviles, Vendrell, Daura, Ventura; (JOURNAL ARTICLE)

False occurrences of functional motifs in protein sequences highlight evolutionary constraints.

Via, Gherardini, Ferraro, Ausiello, Scalia Tomba, Helmer-Citterich; (JOURNAL ARTICLE)

Minimus: a fast, lightweight genome assembler.

Sommer, Delcher, Salzberg, Pop; (JOURNAL ARTICLE)

Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (Encyclopedia of Hepatocellular Carcinoma genes Online).

Hsu, Lai, Liu, Tseng, Lin, Lin, Yeh, Sung, Hsu, Su, Lee, Chen, Lee, Lee, Shiue, Yeh, Chang, Kao, Huang; (JOURNAL ARTICLE)

Kernel-imbedded Gaussian processes for disease classification using microarray gene expression data.

Zhao, Cheung; (JOURNAL ARTICLE)


Bioinformatics

COBALT: COnstraint Based ALignment Tool for Multiple Protein Sequences.

Papadopoulos, Agarwala; (JOURNAL ARTICLE)

NucPred - Predicting Nuclear Localization of Proteins.

Brameier, Krings, Maccallum; (JOURNAL ARTICLE)

Multiple structural alignment and clustering of RNA sequences.

Torarinsson, Havgaard, Gorodkin; (JOURNAL ARTICLE)

Improving metabolic flux estimation via evolutionary optimization for convex solution space.

Chen, Zheng, Liu, Niu, Liu, Shen, Rui, Shi; (JOURNAL ARTICLE)

PhyloGena - a user-friendly system for automated phylogenetic annotation of unknown sequences.

Kristian, Bohnebeck, Beszteri, Valentin; (JOURNAL ARTICLE)

SwS: a solvation web service for nucleic acids.

Auffinger, Hashem; (JOURNAL ARTICLE)

Phylogenetic exploration of bacterial genomic rearrangements.

Fremez, Faraut, Fichant, Gouzy, Quentin; (JOURNAL ARTICLE)

Microarray Blob-Defect Removal Improves Array Analysis.

Song, Maghsoudi, Li, Fox, Quackenbush, Shirley Liu; (JOURNAL ARTICLE)

CEGMA: a pipeline to accurately annotate core genes in eukaryotic genomes.

Parra, Bradnam, Korf; (JOURNAL ARTICLE)

Enabling high-throughput data management for systems biology: The Bioinformatics Resource Manager.

Shah, Singhal, Klicker, Stephan, Steven Wiley, Waters; (JOURNAL ARTICLE)

rh_tsp_map 3.0: End-to-end radiation hybrid mapping with improved speed and quality control.

Schäffer, Rice, Cook, Agarwala; (JOURNAL ARTICLE)


Proc Natl Acad Sci U S A


N Engl J Med

Left ventricular assist devices and drug therapy in heart failure.

Florea; (Comment, Letter)

Clinical problem-solving. Into the woods.

Safdar, Kaul, Saint; (Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Left ventricular assist devices and drug therapy in heart failure.

Rott, Leibowitz; (Comment, Letter)

Vancomycin-induced immune thrombocytopenia.

Von Drygalski, Curtis, Bougie, McFarland, Ahl, Limbu, Baker, Aster; (Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Bugging tumors to put drugs on target.

Juliano; (Journal Article)

Images in clinical medicine. Erythema ab igne.

Chan, Chiu; (Journal Article)

Drug-induced immune-mediated thrombocytopenia--from purpura to thrombosis.

Warkentin; (Journal Article)

Tolvaptan for hyponatremia.

Weise, Rimmer, Hood; (Comment, Letter)

Islet transplantation.

Meyer; (Comment, Letter)

An ongoing study of anemia correction in chronic kidney disease.

Pfeffer; (Letter)

Chloroquine-resistant malaria in Malawi.

Ursing, Rodrigues, Kofoed; (Comment, Letter)

Left ventricular assist devices and drug therapy in heart failure.

Vanderwilt; (Comment, Letter)

Improving the management of chronic disease at community health centers.

Landon, Hicks, O'Malley, Lieu, Keegan, McNeil, Guadagnoli; (Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Performance measurement in search of a path.

Hayward; (Comment, Editorial)

Chloroquine-resistant malaria in Malawi.

Muula; (Comment, Letter)

The patient as ally--learning the pelvic examination.

Wolfberg; (Journal Article)

Professionalism.

Baker; (Comment, Letter)

Financial relationships of institutional review board members.

Miller; (Comment, Letter)

Left ventricular assist devices and drug therapy in heart failure.

Burniston; (Comment, Letter)

Chronic kidney disease, anemia, and epoetin.

Riley; (Comment, Letter)

Cesarean delivery and the risk-benefit calculus.

Ecker, Frigoletto; (Journal Article)

Pay for performance in commercial HMOs.

Sandy, Ile; (Comment, Letter)

Case 36-2006: a pregnant woman with new hypertension.

Lindheimer; (Comment, Letter)

Safety and efficacy of a recombinant hepatitis E vaccine.

Shrestha, Scott, Joshi, Mammen, Thapa, Thapa, Myint, Fourneau, Kuschner, Shrestha, David, Seriwatana, Vaughn, Safary, Endy, Innis; (Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Images in clinical medicine. Gastric-outlet obstruction.

Franco, Dryden; (Journal Article)

Amiodarone for atrial fibrillation.

Zimetbaum; (Journal Article)

Treatment of periodontitis and endothelial function.

Tonetti, D'Aiuto, Nibali, Donald, Storry, Parkar, Suvan, Hingorani, Vallance, Deanfield; (Journal Article, Research Support, Non-U.S. Gov't)

Hepatitis E vaccine--ready for prime time?

Krawczynski; (Comment, Editorial)


J Natl Cancer Inst


Lancet

Thrombosis: the last frontier of coronary stenting?

Urban, De Benedetti; (Comment, Journal Article)

Child wellbeing in rich countries.

none; (Editorial)

Ronald Gray: collaborating with Ugandan researchers on HIV trials.

Boseley; (Biography, Historical Article, News)

Dental caries and social deprivation.

Jain, Shankar, Ramaiah; (Comment, Letter)

Should Europe fortify a staple food with folic acid?

Abramsky, Dolk; (Letter)

Medicalisation in the 21st century: introduction.

Metzl, Herzig; (Journal Article)

Progress in tuberculosis control and the evolving public-health system in China.

Wang, Liu, Chin; (Journal Article)

Type I and type IV allergy to the insulin analogue detemir.

Sola-Gazagnes, Pecquet, M'Bemba, Larger, Slama; (Letter)

Newer approaches to HIV prevention.

none; (Editorial)

Medicalisation: a medical nemesis.

McLellan; (Journal Article)

Male circumcision and HIV/AIDS: challenges and opportunities.

Sawires, Dworkin, Fiamma, Peacock, Szekeres, Coates; (Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Worsening security in Darfur could reverse health gains.

Brown; (News)

US NIH chief gains greater power over budget.

Bristol; (News)

Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial.

Bailey, Moses, Parker, Agot, Maclean, Krieger, Williams, Campbell, Ndinya-Achola; (Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Facial weakness in a haemodialysis patient.

Papadakis, Fee, Wilhelm, Davenport, Connolly; (Case Reports, Journal Article)

HIV-1 in Taiwan.

Chen, Kuo; (Journal Article)

Statins audit: wrong question, wrong conclusions.

Moon, Bogle, Minas; (Comment, Letter)

Beyond medicalisation.

Rose; (Historical Article, Journal Article)

Hospital management of Mumbai train blast victims.

Deshpande, Mehta, Kshirsagar; (Comment, Letter)

Rules of the game of scientific writing: fair play and plagiarism.

Vessal, Habibzadeh; (Letter)

Medicalisation of race.

Duster; (Journal Article, Review)

Health equity funds in Cambodia.

Van Leemput, Ponsar, Philips, Brikci; (Comment, Letter)

Public health versus political frontiers.

none; (Editorial)

Bullets, balance, or both: medicalisation in HIV treatment.

Patton; (Journal Article)

Male circumcision to cut HIV risk in the general population.

Newell, Bärnighausen; (Comment, Journal Article)

HIV/AIDS in China: the numbers problem.

Hesketh; (Comment, Journal Article)

Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study.

Daemen, Wenaweser, Tsuchida, Abrecht, Vaina, Morger, Kukreja, Jüni, Sianos, Hellige, van Domburg, Hess, Boersma, Meier, Windecker, Serruys; (Journal Article, Research Support, Non-U.S. Gov't)

Evolution of China's response to HIV/AIDS.

Wu, Sullivan, Wang, Rotheram-Borus, Detels; (Journal Article, Research Support, N.I.H., Extramural, Review)

Saving the survivors.

Molyneux; (Letter)

Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial.

Gray, Kigozi, Serwadda, Makumbi, Watya, Nalugoda, Kiwanuka, Moulton, Chaudhary, Chen, Sewankambo, Wabwire-Mangen, Bacon, Williams, Opendi, Reynolds, Laeyendecker, Quinn, Wawer; (Journal Article, Randomized Controlled Trial)

Health-system reforms to control tuberculosis in China.

Sleigh; (Comment, Journal Article)

The need for strong general health services in India and elsewhere.

Devadasan, Boelaert, Criel, Van Damme, Gryseels; (Comment, Letter)

If direct-to-consumer advertisements come to Europe: lessons from the USA.

Metzl; (Journal Article, Research Support, N.I.H., Extramural)

Biological control of dengue virus vectors.

Venning; (Comment, Letter)

Patient empowerment and the dilemmas of late-modern medicalisation.

Tomes; (Journal Article, Research Support, Non-U.S. Gov't, Review)


Expert Rev Mol Diagn

Nanotechnology in the diagnosis and management of heart, lung and blood diseases.

Buxton; (Journal Article)

New tracheobronchial stent system launched by Alveolus, Inc.

none; (JOURNAL ARTICLE)

Genetic contributions to Type 2 diabetes: recent insights.

Sale, Rich; (Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Genomics and proteomics approaches in understanding tumor angiogenesis.

Mittal, Nolan; (Journal Article)

Strategies to reduce late-stage drug attrition due to mitochondrial toxicity.

Dykens, Marroquin, Will; (Journal Article)

Adipokines and melanocortins in the hepatic manifestation of metabolic syndrome: nonalcoholic fatty liver disease.

Baranova, Randhawa, Jarrar, Younossi; (Journal Article, Research Support, Non-U.S. Gov't)

Modeling inflammatory bowel disease: the zebrafish as a way forward.

Love, Lan, Dodd, Shelling, McNabb, Ferguson; (Journal Article, Research Support, Non-U.S. Gov't)

Targeting therapeutics: closing the gap between bench and bedside--a focus on tissue microarrays.

Warford; (Interview)

Multiple biomarkers in molecular oncology. I. Molecular diagnostics applications in cervical cancer detection.

Malinowski; (Journal Article)

Cambridge Healthtech Institute's 7th annual, identifying and validating metabolic markers for drug development and clinical studies.

Beger; (Journal Article)