Nature

Erkko, Xia, Nikkilä, Schleutker, Syrjäkoski, Mannermaa, Kallioniemi, Pylkäs, Karppinen, Rapakko, Miron, Sheng, Li, Mattila, Bell, Haber, Grip, Reiman, Jukkola-Vuorinen, Mustonen, Kere, Aaltonen, Kosma, Kataja, Soini, Drapkin, Livingston, Winqvist; (JOURNAL ARTICLE)

Africa pursues goal of scientific unity.

Masood; (News)

Climate change 2007: what price a cooler future?

Odling-Smee; (News)

Energy efficiency: super savers: meters to manage the future.

Butler; (News)

Is the global carbon market working?

Wara; (Journal Article)

Welcome home.

none; (Editorial)

Dig links Stonehenge to circle of life.

Odling-Smee; (Historical Article, News)

Continental ice in Greenland during the Eocene and Oligocene.

Eldrett, Harding, Wilson, Butler, Roberts; (JOURNAL ARTICLE)

Coherent control of optical information with matter wave dynamics.

Ginsberg, Garner, Hau; (Journal Article)

CD38 is critical for social behaviour by regulating oxytocin secretion.

Jin, Liu, Hirai, Torashima, Nagai, Lopatina, Shnayder, Yamada, Noda, Seike, Fujita, Takasawa, Yokoyama, Koizumi, Shiraishi, Tanaka, Hashii, Yoshihara, Higashida, Islam, Yamada, Hayashi, Noguchi, Kato, Okamoto, Matsushima, Salmina, Munesue, Shimizu, Mochida, Asano, Higashida; (JOURNAL ARTICLE)

Large temperature drop across the Eocene-Oligocene transition in central North America.

Zanazzi, Kohn, MacFadden, Terry; (Historical Article, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses.

Radoshitzky, Abraham, Spiropoulou, Kuhn, Nguyen, Li, Nagel, Schmidt, Nunberg, Andrews, Farzan, Choe; (JOURNAL ARTICLE)

Steady progress.

none; (Editorial)

Climate change 2007: what they're saying.

none; (News)

Patterning of sodium ions and the control of electrons in sodium cobaltate.

Roger, Morris, Tennant, Gutmann, Goff, Hoffmann, Feyerherm, Dudzik, Prabhakaran, Boothroyd, Shannon, Lake, Deen; (Journal Article)

Don't stop me now.

Danger; (Journal Article)

How important is immune memory to invertebrates?

Fellous; (Comment, Letter)

Colour-blindness: how to alienate a grant reviewer.

Ross; (Comment, Letter)

Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models.

Kreitzer, Malenka; (In Vitro, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Female fur seals show active choice for males that are heterozygous and unrelated.

Hoffman, Forcada, Trathan, Amos; (JOURNAL ARTICLE)

Palaeoclimate: when the world turned cold.

Bowen; (Comment, Historical Article, News)

An African origin for the intimate association between humans and Helicobacter pylori.

Linz, Balloux, Moodley, Manica, Liu, Roumagnac, Falush, Stamer, Prugnolle, van der Merwe, Yamaoka, Graham, Perez-Trallero, Wadstrom, Suerbaum, Achtman; (JOURNAL ARTICLE)

Energy efficiency: super savers: experimenting with efficiency.

Corbyn; (News)

Carbon copies.

Marris; (Journal Article)

Light at the end of the tunnel.

none; (Editorial)

TRAPPI tethers COPII vesicles by binding the coat subunit Sec23.

Cai, Yu, Menon, Cai, Lazarova, Fu, Reinisch, Hay, Ferro-Novick; (JOURNAL ARTICLE)

Climate change 2007: lifting the taboo on adaptation.

Pielke, Prins, Rayner, Sarewitz; (Journal Article)

Climate change 2007: climate sceptics switch focus to economics.

Hopkin; (News)

Science

A fuel for small farms.

Kintisch; (News)

Science careers. Covering the planet with solar panels.

Webb; (Journal Article)

Andrew Blakers and Klaus Weber profile. Eureka Moment Puts Sliced Solar Cells on Track.

Normile; (News)

2008 U.S. budget. Research rises--and falls--in the president's spending plan.

Mervis; (News)

Clint Chapple profile. How to make biofuels truly poplar.

Kintisch; (News)

Steven Chu profile. Steering a national lab into the light.

Service; (News)

Jay Keasling profile. Rethinking mother nature's choices.

Service; (News)

Ethanol for a sustainable energy future.

Goldemberg; (Journal Article)

James Dumesic profile. Catalyzing the emergence of a practical biorefinery.

Cho; (News)

Rapid Changes in Ice Discharge from Greenland Outlet Glaciers.

Howat, Joughin, Scambos; (JOURNAL ARTICLE)

Microfluidic bubble logic.

Prakash, Gershenfeld; (Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Photovoltaics in focus.

Bohannon; (News)

Reversal of Neurological Defects in a Mouse Model of Rett Syndrome.

Guy, Gan, Selfridge, Cobb, Bird; (JOURNAL ARTICLE)

An Intrinsic Bond-Centered Electronic Glass with Unidirectional Domains in Underdoped Cuprates.

Kohsaka, Taylor, Fujita, Schmidt, Lupien, Hanaguri, Azuma, Takano, Eisaki, Takagi, Uchida, Davis; (JOURNAL ARTICLE)

Crystal Structures of the Adenylate Sensor from Fission Yeast AMP-Activated Protein Kinase.

Townley, Shapiro; (JOURNAL ARTICLE)

A sustainable future, if we pay up front.

Clery; (News)

Debra Rolison profile. Small thinking, electrified froth, and the beauty of a fine mess.

Coontz; (News)

Stem cells. Controversial marrow cells coming into their own?

Holden; (News)

2008 U.S. budget. Science adviser battles cancer.

Mervis; (News)

Science and society. Time for a new era of science diplomacy.

Lord, Turekian; (Journal Article)

Climate change. U.S. policy: a permanent sea change?

Kerr; (News)

Science careers. Getting on the grid: bringing remote, intermittent energy sources into line.

Austin; (Journal Article)

African science. African leaders endorse science initiatives.

Koenig; (News)

Evidence that focal adhesion complexes power bacterial gliding motility.

Mignot, Shaevitz, Hartzell, Zusman; (Journal Article, Research Support, N.I.H., Extramural)

Stem cells. Stem cell candidates proliferate.

Holden; (News)

Cell biology. Cellular demolition and the rules of engagement.

Youle; (Comment, Journal Article)

Physics. International team releases design, cost for next great particle smasher.

Cho; (News)

Daniel Nocera profile. Hydrogen economy? Let sunlight do the work.

Service; (News)

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis, Fletcher, Kaufmann, van Delft, Chen, Czabotar, Ierino, Lee, Fairlie, Bouillet, Strasser, Kluck, Adams, Huang; (Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Energy research. BP bets big on UC Berkeley for novel biofuels center.

Kintisch; (News)

Oceans. Picoplankton do some heavy lifting.

Barber; (Comment, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Wiring up Europe's coastline.

Clery; (News)

Energy and sustainability.

Holdren; (Editorial)

Energy for the long haul.

Szuromi, Jasny, Clery, Austin, Hanson; (Journal Article)

CPD damage recognition by transcribing RNA polymerase II.

Brueckner, Hennecke, Carell, Cramer; (Journal Article, Research Support, Non-U.S. Gov't)

Limits to the Human Cancer Genome Project?

Chng; (Comment, Letter)

Enceladus: cosmic graffiti artist caught in the act.

Verbiscer, French, Showalter, Helfenstein; (Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".

Chartrel, Alvear-Perez, Leprince, Iturrioz, Reaux-Le Goazigo, Audinot, Chomarat, Coge, Nosjean, Rodriguez, Galizzi, Boutin, Vaudry, Llorens-Cortes; (Comment, Journal Article)

Chemistry. Can droplets and bubbles think?

Epstein; (Comment, Journal Article)

Preparing to capture carbon.

Schrag; (Journal Article)

2008 U.S. budget. NSF education program rebounds.

Mervis; (News)

2008 U.S. budget. NIH children's study sparks fight.

Marshall; (News)

Microbiology. Bright insight into bacterial gliding.

Kearns; (Comment, Journal Article)

Toward cost-effective solar energy use.

Lewis; (Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Studying students in Montessori schools.

Mackinnon; (Comment, Letter)

Brain, Music, and Sound Research Center. Study of music and the mind hits a high note in Montreal.

Balter; (News)

Science careers. From greener production to carbon trading: sustainable energy careers.

Bohannon; (Journal Article)

Biomass recalcitrance: engineering plants and enzymes for biofuels production.

Himmel, Ding, Johnson, Adney, Nimlos, Brady, Foust; (Journal Article)

Steven Koonin profile. Guiding an oil tanker into renewable waters.

Clery; (News)

Gene expression and ethnic differences.

Billinger; (Comment, Letter)

A common explosion mechanism for type Ia supernovae.

Mazzali, Röpke, Benetti, Hillebrandt; (Journal Article, Research Support, Non-U.S. Gov't)

Tariq Rauf profile. Treading the nuclear fuel cycle minefield.

Bohannon; (News)

2008 U.S. budget. NASA tries to make space for science.

Lawler; (News)

Don't forget long-term fundamental research in energy.

Whitesides, Crabtree; (Journal Article)

Atmospheric science. Pumping up surface air.

Jaeglé; (Comment, Journal Article)

Scientific workforce. Racism allegations taint Chinese effort to recruit overseas talent.

Hao; (News)

Biophysics. Antennae as gyroscopes.

Alexander; (Comment, Journal Article)

Climate change. Scientists tell policymakers we're all warming the world.

Kerr; (News)

Medicine. Rett symptoms reversed in mice.

Miller; (News)

Relative impact of nucleotide and copy number variation on gene expression phenotypes.

Stranger, Forrest, Dunning, Ingle, Beazley, Thorne, Redon, Bird, de Grassi, Lee, Tyler-Smith, Carter, Scherer, Tavaré, Deloukas, Hurles, Dermitzakis; (Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Small phytoplankton and carbon export from the surface ocean.

Richardson, Jackson; (Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Challenges in engineering microbes for biofuels production.

Stephanopoulos; (Journal Article)

Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G.

Roche, Rey, Gaudin, Bressanelli; (Journal Article, Research Support, Non-U.S. Gov't)

Antennal mechanosensors mediate flight control in moths.

Sane, Dieudonné, Willis, Daniel; (Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Renewable energy sources and the realities of setting an energy agenda.

Potocnik; (Journal Article)

Norway. A nuclear demonstration project?

Clery; (News)

Richard Martineau profile. Former marine seeks a model EMPRESS.

Kintisch; (News)

Nature Methods

Ubc9 fusion-directed SUMOylation (UFDS): a method to analyze function of protein SUMOylation.

Jakobs, Koehnke, Himstedt, Funk, Korn, Gaestel, Niedenthal; (JOURNAL ARTICLE)

Focused-ion-beam thinning of frozen-hydrated biological specimens for cryo-electron microscopy.

Marko, Hsieh, Schalek, Frank, Mannella; (JOURNAL ARTICLE)

A retroviral strategy that efficiently creates chromosomal deletions in mammalian cells.

Bilodeau, Girard, Hébert, Sauvageau; (JOURNAL ARTICLE)

Nature Biotechnology

Profile: jean-paul clozel.

Schmidt; (Journal Article)

Response to Blame factory farming, not organic food.

none; (Journal Article)

Adaptation to culture of human embryonic stem cells and oncogenesis in vivo.

Baker, Harrison, Maltby, Smith, Moore, Shaw, Heath, Holden, Andrews; (Journal Article)

Reality check for device-drug convergence.

Ratner; (Journal Article)

Next-generation sequencing outpaces expectations.

Shaffer; (Journal Article)

People.

none; (Journal Article)

Strength in diversity: a cross-disciplinary approach to graduate training in chemical biology.

Silvius; (Journal Article)

Research highlights.

none; (Journal Article)

Chinese biotech hamstrung by production issues.

Jia; (Journal Article)

The fit between organic and pharma crops in North Carolina.

Williams; (Journal Article)

Blame factory farming, not organic food.

Holdrege; (Journal Article)

Corrigendum: Expression of artificial microRNAs in transgenic Arabidopsis thaliana confers virus resistance.

Niu, Lin, Reyes, Chen, Wu, Yeh, Chua; (Journal Article)

The genome of an industrial workhorse.

Cullen; (Journal Article)

Commercial interest grows in glycan analysis.

Sheridan; (Journal Article)

Bringing antivenoms to Sub-Saharan Africa.

Stock, Massougbodji, Alagón, Chippaux; (Journal Article)

Targeting brain-tumor stem cells.

Stupp, Hegi; (JOURNAL ARTICLE)

Hearts and minds.

none; (Journal Article)

Life support for life science innovation?

none; (Journal Article)

Relating protein pharmacology by ligand chemistry.

Keiser, Roth, Armbruster, Ernsberger, Irwin, Shoichet; (JOURNAL ARTICLE)

Managing innovation in a global industry.

Casper; (Journal Article)

News in brief.

none; (Journal Article)

Corrigendum: Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell-derived hepatocytes.

Soto-Gutiérrez, Kobayashi, Rivas-Carrillo, Navarro-Alvarez, Zhao, Okitsu, Noguchi, Basma, Tabata, Chen, Tanaka, Narushima, Miki, Ueda, Jun, Yoon, Lebkowski, Tanaka, Fox; (Journal Article)

DNA patenting: the end of an era?

Hopkins, Mahdi, Patel, Thomas; (Journal Article)

Response to The fit between organic and pharma crops in North Carolina.

none; (Journal Article)

Getting it right the first time.

Johnson; (Journal Article)

Model for tuning GMO detection in seed and grain.

Macarthur, Murray, Allnutt, Deppe, Hird, Kerins, Blackburn, Brown, Stones, Hugo; (Journal Article)

ATP and FRET-a cautionary note.

Willemse, Janssen, Lange, Wieringa, Fransen; (Journal Article)

Erratum: Rainbow biotech-South Africa's emerging sector.

Louët; (Journal Article)

Calreticulin exposure increases cancer immunogenicity.

Clarke, Smyth; (Journal Article)

A stellar year for financing.

Lawrence; (Journal Article)

Genetically modified lignin below ground.

Hopkins, Webster, Boerjan, Pilate, Halpin; (Journal Article)

Recent patent applications in biomedical devices.

none; (Journal Article)

Democrats prioritize pricing, generics and drug safety.

Fox; (Journal Article)

Lentiviruses to the placental rescue.

Cross; (Journal Article)

Turning biodefense dollars into products.

Trull, du Laney, Dibner; (Journal Article)

Nature Medicine

US proposal to expand access to untested drugs draws fire.

Waltz; (Journal Article)

Large stem cell grafts could lead to erroneous interpretations of behavioral results?

Christophersen, Brundin; (Journal Article)

A prize catch for diabetic retinopathy.

Gardner, Antonetti; (Journal Article)

Safeguarding clinical trials.

none; (Journal Article)

Ambitious scheme for developing world trials in 'big trouble'.

Keim; (Journal Article)

Eating bone or adding it: the Wnt pathway decides.

Goldring, Goldring; (Journal Article)

Reformed US malaria program garners critics' approval.

Schubert; (Journal Article)

Australia set to test insulin 'vaccine' for juvenile diabetes.

Grose; (Journal Article)

Large stem cell grafts could lead to erroneous interpretations of behavioral results?

Goldman, Roy, Beal, Cleren; (Journal Article)

Corrigendum: In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'.

Gambacorti-Passerini, Tornaghi, Franceschino, Piazza, Corneo, Pogliani; (Journal Article)

Receptor feasts on sugar and cholesterol.

Rodgers, Puigserver; (Journal Article)

Gut warfare.

Check; (Journal Article)

A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage.

Steinman; (Journal Article)

ACE inhibitor bulks up muscle.

Chamberlain; (Journal Article)

Orexins: looking forward to sleep, back at addiction.

Scammell, Saper; (Journal Article)

Research highlights.

none; (Journal Article)

Supplement makers face bitter pill.

Wadman; (Journal Article)

Where is the problem in the Ramón y Cajal program?

Sanz-Menéndez; (Journal Article)

Biomass fuels blamed for premature deaths in rural settings.

Padma; (Journal Article)

Tied up in red tape, European trials shut down.

Keim; (Journal Article)

British scientists find patent loophole.

Keim; (Journal Article)

Seeing what Alzheimer saw.

de Leon, Mosconi, Logan; (Journal Article)

Vikram kumar.

Keim; (Journal Article)

The past, present and future of neural prosthetics.

Taylor; (JOURNAL ARTICLE)

News in brief.

none; (Journal Article)

Nature Genetics

Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta.

Cabral, Chang, Barnes, Weis, Scott, Leikin, Makareeva, Kuznetsova, Rosenbaum, Tifft, Bulas, Kozma, Smith, Eyre, Marini; (JOURNAL ARTICLE)

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

Yamanouchi, Rainbow, Serra, Howlett, Hunter, Garner, Gonzalez-Munoz, Clark, Veijola, Cubbon, Chen, Rosa, Cumiskey, Serreze, Gregory, Rogers, Lyons, Healy, Smink, Todd, Peterson, Wicker, Santamaria; (JOURNAL ARTICLE)

Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species.

Man, Pilpel; (JOURNAL ARTICLE)

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.

Heintzman, Stuart, Hon, Fu, Ching, Hawkins, Barrera, Van Calcar, Qu, Ching, Wang, Weng, Green, Crawford, Ren; (JOURNAL ARTICLE)

Molecular Medicine

Proteomics

WI-PHI: A weighted yeast interactome enriched for direct physical interactions.

Kiemer, Costa, Ueffing, Cesareni; (JOURNAL ARTICLE)

Proteomic analysis of the oxidative stress response in Candida albicans.

Kusch, Engelmann, Albrecht, Morschhäuser, Hecker; (JOURNAL ARTICLE)

(15)N-Metabolic labeling for comparative plasma membrane proteomics in Arabidopsis cells.

Lanquar, Kuhn, Lelièvre, Khafif, Espagne, Bruley, Barbier-Brygoo, Garin, Thomine; (JOURNAL ARTICLE)

Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein-protein interaction networks?

Schnell, Fortunato, Roy; (JOURNAL ARTICLE)

Nature Drug Discovery

BMC Bioinformatics

WeederH: an algorithm for finding conserved regulatory motifs and regions in homologous sequences.

Pavesi, Zambelli, Pesole; (JOURNAL ARTICLE)

MetaQTL: a package of new computational methods for the meta-analysis of QTL mapping experiments.

Veyrieras, Goffinet, Charcosset; (JOURNAL ARTICLE)

Predictive modeling of plant messenger RNA polyadenylation sites.

Ji, Zheng, Shen, Wu, Jiang, Lin, Loke, Davis, Reese, Li; (JOURNAL ARTICLE)

Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Kinase 2.

Gu, Bourne; (JOURNAL ARTICLE)

Improved precision and accuracy for microarrays using updated probe set definitions.

Sandberg, Larsson; (JOURNAL ARTICLE)

Hon-yaku: a biology-driven Bayesian methodology for identifying translation initiation sites in prokaryotes.

Makita, de Hoon, Danchin; (JOURNAL ARTICLE)

Predicting zinc binding at the proteome level.

Passerini, Andreini, Menchetti, Rosato, Frasconi; (JOURNAL ARTICLE)

NeuroTerrain - a client-server system for browsing 3D biomedical image data sets.

Gustafson, Bug, Nissanov; (JOURNAL ARTICLE)

FUNC: a package for detecting significant associations between gene sets and ontological annotations.

Prufer, Muetzel, Do, Weiss, Khaitovich, Rahm, Paabo, Lachmann, Enard; (JOURNAL ARTICLE)

Ranked Adjusted Rand: integrating distance and partition information in a measure of clustering agreement.

Pinto, Carrico, Ramirez, Almeida; (JOURNAL ARTICLE)

PlnTFDB: An integrative plant transcription factor database.

Riano-Pachon, Ruzicic, Dreyer, Mueller-Roeber; (JOURNAL ARTICLE)

Bioinformatics

Automatic Correspondence of Tags and Genes (ACTG): A Tool for the Analysis of SAGE, MPSS, and SBS Data.

Galante, Trimarchi, Cepko, de Souza, Ohno-Machado, Kuo; (JOURNAL ARTICLE)

SCOOP: A simple method for identification of novel protein superfamily relationships.

Bateman, Finn; (JOURNAL ARTICLE)

NetMatch: a Cytoscape Plugin for Searching Biological Networks.

Ferro, Giugno, Pigola, Pulvirenti, Skripin, Bader, Shasha; (JOURNAL ARTICLE)

NetPhosYeast: Prediction of protein phosphorylation sites in yeast.

Ingrell, Miller, Jensen, Blom; (JOURNAL ARTICLE)

DFprot: A webtool for predicting local chain deformability.

Garzón, Kovacs, Abagyan, Chacón; (JOURNAL ARTICLE)

Disease-Specific Genomic Analysis: Identifying the Signature of Pathologic Biology.

Nicolau, Tibshirani, Børresen-Dale, Jeffrey; (JOURNAL ARTICLE)

Hardware acceleration of processing of mass spectrometric data for proteomics.

Bogdan, Coca, Rivers, Beynon; (JOURNAL ARTICLE)

Assessment of the probabilities for evolutionary structural changes in protein folds.

Viksna, Gilbert; (JOURNAL ARTICLE)

Proc Natl Acad Sci U S A

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.

Seita, Ema, Ooehara, Yamazaki, Tadokoro, Yamasaki, Eto, Takaki, Takatsu, Nakauchi; (Journal Article)

Adaptations to fluctuating selection in Drosophila.

Mustonen, Lässig; (Journal Article)

Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis.

Urushitani, Ezzi, Julien; (Journal Article)

From the Cover: Eukaryotic RNase P RNA mediates cleavage in the absence of protein.

Kikovska, Svärd, Kirsebom; (Journal Article)

Role of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1.

Zhang, Yang, Chen, Feser, Huang; (Journal Article)

Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.

Arai, Miyake, Voit, Nemoto, Wakeland, Grummt, Miyazaki; (Journal Article)

Silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.

Musatov, Chen, Pfaff, Mobbs, Yang, Clegg, Kaplitt, Ogawa; (Journal Article)

Identification of prostate cancer mRNA markers by averaged differential expression and their detection in biopsies, blood, and urine.

Bai, Kaseb, Tejwani, Divine, Barrack, Menon, Pardee, Reddy; (Journal Article)

Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Chi, Huttenhower, Geer, Coon, Syka, Bai, Shabanowitz, Burke, Troyanskaya, Hunt; (Journal Article)

Plasticity of genetic interactions in metabolic networks of yeast.

Harrison, Papp, Pál, Oliver, Delneri; (Journal Article)

Uniformity amid diversity in RNase P.

Gopalan; (Journal Article)

Diazonamide toxins reveal an unexpected function for ornithine {delta}-amino transferase in mitotic cell division.

Wang, Shang, Burgett, Harran, Wang; (Journal Article)

Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI).

Lu, Xi, Gitajn, Rea, Yang, Stein; (Journal Article)

Aquaglyceroporin PbAQP during intraerythrocytic development of the malaria parasite Plasmodium berghei.

Promeneur, Liu, Maciel, Agre, King, Kumar; (Journal Article)

Probing the interactions of proteins and nanoparticles.

Klein; (Journal Article)

Brain shape in human microcephalics and Homo floresiensis.

Falk, Hildebolt, Smith, Morwood, Sutikna, Jatmiko, Saptomo, Imhof, Seidler, Prior; (Journal Article)

Virstatin inhibits dimerization of the transcriptional activator ToxT.

Shakhnovich, Hung, Pierson, Lee, Mekalanos; (Journal Article)

Lifelong accumulation of bone in mice lacking Pten in osteoblasts.

Liu, Bruxvoort, Zylstra, Liu, Cichowski, Faugere, Bouxsein, Wan, Williams, Clemens; (Journal Article)

Disulfide formation as a probe of folding in GroEL-GroES reveals correct formation of long-range bonds and editing of incorrect short-range ones.

Park, Fenton, Horwich; (Journal Article)

Internal strain regulates the nucleotide binding site of the kinesin leading head.

Hyeon, Onuchic; (Journal Article)

Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression.

Parrish, Resch, Moss; (Journal Article)

Discovery of growth hormone-releasing hormones and receptors in nonmammalian vertebrates.

Lee, Siu, Tam, Lau, Wong, Lin, Vaudry, Chow; (Journal Article)

From the Cover: Dietary sequestration of defensive steroids in nuchal glands of the Asian snake Rhabdophis tigrinus.

Hutchinson, Mori, Savitzky, Burghardt, Wu, Meinwald, Schroeder; (Journal Article)

Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

Haruna, Kashihara, Satoh, Tomita, Namikoshi, Sasaki, Fujimori, Xie, Kanwar; (Journal Article)

Phase-variable expression of a family of glycoproteins imparts a dynamic surface to a symbiont in its human intestinal ecosystem.

Fletcher, Coyne, Bentley, Villa, Comstock; (Journal Article)

Queen pheromone modulates brain dopamine function in worker honey bees.

Beggs, Glendining, Marechal, Vergoz, Nakamura, Slessor, Mercer; (Journal Article)

Specific polysaccharide conjugate vaccine-induced IgG antibodies prevent invasion of Shigella into Caco-2 cells and may be curative.

Chowers, Kirschner, Keller, Barshack, Bar-Meir, Ashkenazi, Schneerson, Robbins, Passwell; (Journal Article)

1-Methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKC{delta} enzymatic activities.

Serulle, Morfini, Pigino, Moreira, Sugimori, Brady, Llinás; (Journal Article)

1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C.

Morfini, Pigino, Opalach, Serulle, Moreira, Sugimori, Llinás, Brady; (Journal Article)

From the Cover: Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis.

Nakazawa, Hisatomi, Nakazawa, Noda, Maruyama, She, Matsubara, Miyahara, Nakao, Yin, Benowitz, Hafezi-Moghadam, Miller; (Journal Article)

Wnt signaling interacts with Shh to regulate taste papilla development.

Iwatsuki, Liu, Grónder, Singer, Lane, Grosschedl, Mistretta, Margolskee; (Journal Article)

Thermodynamic analysis of progesterone receptor-promoter interactions reveals a molecular model for isoform-specific function.

Connaghan-Jones, Heneghan, Miura, Bain; (Journal Article)

Assessment of nitric oxide signals by triiodide chemiluminescence.

Hausladen, Rafikov, Angelo, Singel, Nudler, Stamler; (Journal Article)

Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae.

Vemuri, Eiteman, McEwen, Olsson, Nielsen; (Journal Article)

Direct measurement of force generation by actin filament polymerization using an optical trap.

Footer, Kerssemakers, Theriot, Dogterom; (Journal Article)

Common mechanisms of target cell recognition and immunity for class II bacteriocins.

Diep, Skaugen, Salehian, Holo, Nes; (JOURNAL ARTICLE)

Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1.

Nigrovic, Binstadt, Monach, Johnsen, Gurish, Iwakura, Benoist, Mathis, Lee; (Journal Article)

How to keep photoreceptors alive.

Bird; (Journal Article)

Restoring species-specific posttransfer editing activity to a synthetase with a defunct editing domain.

Sternjohn, Hati, Siliciano, Musier-Forsyth; (Journal Article)

Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.

Lin, Hsu, Tarn; (Journal Article)

From the Cover: Targeted cell killing by reconstituted caspases.

Chelur, Chalfie; (Journal Article)

Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2.

Kastning, Kukhtina, Kittler, Chen, Pechstein, Enders, Lee, Sheng, Yan, Haucke; (JOURNAL ARTICLE)

Light-powering Escherichia coli with proteorhodopsin.

Walter, Greenfield, Bustamante, Liphardt; (Journal Article)

Escherichia coli enzyme IIANtr regulates the K+ transporter TrkA.

Lee, Cho, Yoon, Peterkofsky, Seok; (JOURNAL ARTICLE)

X-ray fluorescence microscopy reveals large-scale relocalization and extracellular translocation of cellular copper during angiogenesis.

Finney, Mandava, Ursos, Zhang, Rodi, Vogt, Legnini, Maser, Ikpatt, Olopade, Glesne; (Journal Article)

Indirect activation of a plant nucleotide binding site-leucine-rich repeat protein by a bacterial protease.

Ade, Deyoung, Golstein, Innes; (Journal Article)

Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice.

Almind, Manieri, Sivitz, Cinti, Kahn; (Journal Article)

Reactive oxygen species detoxification by catalase is a major determinant of fecundity in the mosquito Anopheles gambiae.

Dejong, Miller, Molina-Cruz, Gupta, Kumar, Barillas-Mury; (Journal Article)

Regulation of yeast oscillatory dynamics.

Murray, Beckmann, Kitano; (Journal Article)

Interleukin 7 reduces the levels of spontaneous apoptosis in CD4+ and CD8+ T cells from HIV-1-infected individuals.

Vassena, Proschan, Fauci, Lusso; (Journal Article)

Characterization of Z-DNA as a nucleosome-boundary element in yeast Saccharomyces cerevisiae.

Wong, Chen, Kwon, Rich; (Journal Article)

Open-cap conformation of intramembrane protease GlpG.

Wang, Ha; (Journal Article)

Structure of the cooperative Xis-DNA complex reveals a micronucleoprotein filament that regulates phage lambda intasome assembly.

Abbani, Papagiannis, Sam, Cascio, Johnson, Clubb; (Journal Article)

Kinetic models of redox-coupled proton pumping.

Kim, Wikström, Hummer; (Journal Article)

The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli.

Collins, Beis, Dong, Botting, McDonnell, Ford, Clarke, Whitfield, Naismith; (Journal Article)

Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini.

Taverna, Ueberheide, Liu, Tackett, Diaz, Shabanowitz, Chait, Hunt, Allis; (Journal Article)

The PsbQ protein defines cyanobacterial Photosystem II complexes with highest activity and stability.

Roose, Kashino, Pakrasi; (Journal Article)

Telomere dysfunction as a cause of genomic instability in Werner syndrome.

Crabbe, Jauch, Naeger, Holtgreve-Grez, Karlseder; (Journal Article)

A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.

Jeans, Oliver, Johnson, Capogna, Vikman, Molnár, Babbs, Partridge, Salehi, Bengtsson, Eliasson, Rorsman, Davies; (Journal Article)

Direct action of gonadotropin in brain integrates behavioral and reproductive functions.

Yang, Nasipak, Kelley; (Journal Article)

Transcriptomic analysis of growth heterosis in larval Pacific oysters (Crassostrea gigas).

Hedgecock, Lin, Decola, Haudenschild, Meyer, Manahan, Bowen; (Journal Article)

Identification and functional expression of the Arabidopsis thaliana vacuolar glucose transporter 1 and its role in seed germination and flowering.

Aluri, Büttner; (Journal Article)

Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity.

Williams, Burgett, Atkins, Wang, Harran, McKnight; (Journal Article)

Adaptive genic evolution in the Drosophila genomes.

Shapiro, Huang, Zhang, Hubisz, Lu, Turissini, Fang, Wang, Hudson, Nielsen, Chen, Wu; (Journal Article)

A catalytic beacon sensor for uranium with parts-per-trillion sensitivity and millionfold selectivity.

Liu, Brown, Meng, Cropek, Istok, Watson, Lu; (Journal Article)

An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition.

Eleftherianos, Boundy, Joyce, Aslam, Marshall, Cox, Simpson, Clarke, Ffrench-Constant, Reynolds; (Journal Article)

Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport.

Liu, Ding, Wu, Bhagavatula, Cui, Chu, Mobley, Yang; (Journal Article)

Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.

Molina, Horn, Tang, Mathivanan, Pandey; (Journal Article)

Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion.

Miles, Hartley, Todd, Brownstone; (Journal Article)

Biosynthesis of {gamma}-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.

Kato, Funa, Watanabe, Ohnishi, Horinouchi; (Journal Article)

Sustainability Science: A room of its own.

Clark; (Journal Article)

Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6.

Martinez de la Torre, Buracchi, Borroni, Dupor, Bonecchi, Nebuloni, Pasqualini, Doni, Lauri, Agostinis, Bulla, Cook, Haribabu, Meroni, Rukavina, Vago, Tedesco, Vecchi, Lira, Locati, Mantovani; (Journal Article)

Loop formation in unfolded polypeptide chains on the picoseconds to microseconds time scale.

Fierz, Satzger, Root, Gilch, Zinth, Kiefhaber; (Journal Article)

Deletion of CASK in mice is lethal and impairs synaptic function.

Atasoy, Schoch, Ho, Nadasy, Liu, Zhang, Mukherjee, Nosyreva, Fernandez-Chacon, Missler, Kavalali, Südhof; (Journal Article)

Substrate product equilibrium on a reversible enzyme, triosephosphate isomerase.

Rozovsky, McDermott; (Journal Article)

Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons.

Ster, De Bock, Guérineau, Janossy, Barrère-Lemaire, Bos, Bockaert, Fagni; (Journal Article)

Morphological mechanism of the development of pulmonary emphysema in klotho mice.

Sato, Hirai, Imura, Kita, Iwano, Muro, Nabeshima, Suki, Mishima; (Journal Article)

Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation.

Lefebvre, Jing, Becaficco, Franzini-Armstrong, Granato; (Journal Article)

Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice.

Wilson, Cox; (Journal Article)

Acute postnatal ablation of Hif-2{alpha} results in anemia.

Gruber, Hu, Johnson, Brown, Keith, Simon; (Journal Article)

Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.

Nam, Sliz, Pear, Aster, Blacklow; (Journal Article)

Dynamic oligomeric conversions of the cytoplasmic RCK domains mediate MthK potassium channel activity.

Kuo, Baker, Wong, Choe; (Journal Article)

N Engl J Med

Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.

Legro, Barnhart, Schlaff, Carr, Diamond, Carson, Steinkampf, Coutifaris, McGovern, Cataldo, Gosman, Nestler, Giudice, Leppert, Myers; (Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural)

Clinical practice. The incidentally discovered adrenal mass.

Young; (Journal Article, Review)

Thoracentesis.

Eisen; (Comment, Letter)

DHEA and testosterone in the elderly.

Yasuda, Horie; (Comment, Letter)

Medical education--professionalism.

Balla; (Comment, Letter)

Taking TRIPS to India--Novartis, patent law, and access to medicines.

Mueller; (Journal Article)

Spinal epidural abscess.

Gerstein; (Comment, Letter)

DHEA and testosterone in the elderly.

Perls; (Comment, Letter)

Thoracentesis.

Temes; (Comment, Letter)

Religion, conscience, and controversial clinical practices.

Curlin, Lawrence, Chin, Lantos; (Journal Article, Research Support, N.I.H., Extramural)

Spinal epidural abscess.

de Letona; (Comment, Letter)

Medical education--professionalism.

Howland; (Comment, Letter)

Spinal epidural abscess.

Rigamonti, Metellus; (Comment, Letter)

Medical education--professionalism.

Knopp; (Comment, Letter)

A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis.

Krueger, Langley, Leonardi, Yeilding, Guzzo, Wang, Dooley, Lebwohl; (Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Medical education--professionalism.

Barr; (Comment, Letter)

Colonoscopy screening for detection of advanced neoplasia.

Picca; (Comment, Letter)

Elderly survivors with homozygous sickle cell disease.

Serjeant, Higgs, Hambleton; (Letter)

GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis.

Uchida, Beck, Yamamoto, Berclaz, Abe, Staudt, Carey, Filippi, Wert, Denson, Puchalski, Hauck, Trapnell; (Journal Article, Research Support, N.I.H., Extramural)

Regulatory and judicial oversight of nonprofit hospitals.

Studdert, Mello, Jedrey, Brennan; (Journal Article)

DHEA and testosterone in the elderly.

Gleicher, Barad; (Comment, Letter)

Images in clinical medicine. Urine fluorescence in ethylene glycol poisoning.

McStay, Gordon; (Case Reports, Journal Article)

DHEA and testosterone in the elderly.

Page, Matsumoto, Bremner; (Comment, Letter)

Thailand and the compulsory licensing of efavirenz.

Steinbrook; (Journal Article)

Case records of the Massachusetts General Hospital. Case 4-2007. A 56-year-old woman with rapidly progressive vertigo and ataxia.

Dalmau, Gonzalez, Lerwill; (Case Reports, Clinical Conference, Journal Article)

Colonoscopy screening for detection of advanced neoplasia.

Maisonneuve, Lowenfels; (Comment, Letter)

Antithymocyte globulin versus basiliximab in renal transplantation.

Killen, Chadban; (Comment, Letter)

Treating the polycystic ovary syndrome the old-fashioned way.

Guzick; (Comment, Editorial)

Colonoscopy screening for detection of advanced neoplasia.

Latreille, Anderson; (Comment, Letter)

Images in clinical medicine. Hydrofluoric acid burn.

Dünser, Rieder; (Case Reports, Journal Article)

Pulmonary alveolar proteinosis--is host defense awry?

Doerschuk; (Comment, Journal Article)

J Natl Cancer Inst

Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy.

Hershman, Neugut, Jacobson, Wang, Tsai, McBride, Bennett, Grann; (Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Re: Tissue banks trigger worry about ownership issues.

van Diest, Kummer, Voest; (Comment, Letter)

SNPs not living up to promise; experts suggest new approach to disease ID.

Schmidt; (News)

Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study.

Swerdlow, Higgins, Smith, Cunningham, Hancock, Horwich, Hoskin, Lister, Radford, Rohatiner, Linch; (Journal Article, Research Support, Non-U.S. Gov't)

Quality of reporting of cancer prognostic marker studies: association with reported prognostic effect.

Kyzas, Denaxa-Kyza, Ioannidis; (Journal Article)

Performance of different microsatellite marker panels for detection of mismatch repair-deficient colorectal tumors.

Xicola, Llor, Pons, Castells, Alenda, Piñol, Andreu, Castellví-Bel, Payá, Jover, Bessa, Girós, Duque, Nicolás-Pérez, Garcia, Rigau, Gassull; (Journal Article, Research Support, Non-U.S. Gov't)

Blood, spit, and breath: scientists search for noninvasive tests for lung cancer.

Beckman; (News)

Effect of fibroblast growth factor 2 on stromal cell-derived factor 1 production by bone marrow stromal cells and hematopoiesis.

Nakayama, Mutsuga, Tosato; (Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)

Lung cancer screening debate continues despite international CT study results.

Twombly; (News)

With targeted drugs, chronic myelogenous leukemia therapy may follow HIV's model.

Tuma; (News)

An affair of the heart.

Boice; (Comment, Editorial)

Second cancer incidence and cause-specific mortality among 3104 patients with hairy cell leukemia: a population-based study.

Hisada, Chen, Jaffe, Travis; (Journal Article, Research Support, N.I.H., Intramural)