Nature

Safer embryo tests could boost IVF pregnancy rates.

Pearson; (News)

Brief Communications (RIP) and the soul of wit.

Wolfe; (Journal Article)

Dishing a modern myth about microbes.

Fenchel, Esteban, Finlay; (Letter)

A votre santé: now in pill form?

Check; (News)

Correction.

none; (JOURNAL ARTICLE)

Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis.

Kämper, Kahmann, Bölker, Ma, Brefort, Saville, Banuett, Kronstad, Gold, Müller, Perlin, Wösten, de Vries, Ruiz-Herrera, Reynaga-Peña, Snetselaar, McCann, Pérez-Martín, Feldbrügge, Basse, Steinberg, Ibeas, Holloman, Guzman, Farman, Stajich, Sentandreu, González-Prieto, Kennell, Molina, Schirawski, Mendoza-Mendoza, Greilinger, Münch, Rössel, Scherer, Vranes, Ladendorf, Vincon, Fuchs, Sandrock, Meng, Ho, Cahill, Boyce, Klose, Klosterman, Deelstra, Ortiz-Castellanos, Li, Sanchez-Alonso, Schreier, Häuser-Hahn, Vaupel, Koopmann, Friedrich, Voss, Schlüter, Margolis, Platt, Swimmer, Gnirke, Chen, Vysotskaia, Mannhaupt, Güldener, Münsterkötter, Haase, Oesterheld, Mewes, Mauceli, DeCaprio, Wade, Butler, Young, Jaffe, Calvo, Nusbaum, Galagan, Birren; (Journal Article)

10Be evidence for the Matuyama-Brunhes geomagnetic reversal in the EPICA Dome C ice core.

Raisbeck, Yiou, Cattani, Jouzel; (Journal Article)

Abstractions.

none; (JOURNAL ARTICLE)

Hwang takes the stand at fraud trial.

Cyranoski; (News)

50 & 100 Years Ago.

none; (JOURNAL ARTICLE)

Science in culture: Creativity on the wings of a dove.

Judson; (JOURNAL ARTICLE)

Geochemistry: how well can Pb isotopes date core formation?

Kamber, Kramers; (Comment, Journal Article)

Brief: goodbye to a quirky perspective on science.

Small; (Journal Article)

Islam and Science: steps towards reform.

Fergany; (Journal Article)

How much will it cost to save the world?

none; (News)

Beautiful models.

Nee; (JOURNAL ARTICLE)

Islam and Science: Q and A The reformer. Mostafa Moin interviewed by Declan Butler.

Moin; (Interview)

The daunting process of MIAME.

Galbraith; (Comment, Letter)

Insights into social insects from the genome of the honeybee Apis mellifera.

; (Journal Article)

A global call to arms.

none; (Editorial)

In brief.

none; (JOURNAL ARTICLE)

Geochemistry: does U-Pb date Earth's core formation?

Yin, Jacobsen; (Comment, Journal Article)

Islam and science: where are the new patrons of science?

Schopper; (Journal Article)

Evolutionary biology: to work or not to work.

Queller; (Comment, News)

Global distribution and conservation of rare and threatened vertebrates.

Grenyer, Orme, Jackson, Thomas, Davies, Davies, Jones, Olson, Ridgely, Rasmussen, Ding, Bennett, Blackburn, Gaston, Gittleman, Owens; (Journal Article)

A jumping off point.

Lewis; (Journal Article)

Science and the islamists.

none; (Editorial)

Radiation-pressure cooling and optomechanical instability of a micromirror.

Arcizet, Cohadon, Briant, Pinard, Heidmann; (Journal Article)

Research highlights.

none; (JOURNAL ARTICLE)

Geophysics: same old magnetism.

Irving; (Comment, News)

Enough biodefence.

none; (Editorial)

Materials science: qubits in the pink.

Kok, Lovett; (News)

Proterozoic low orbital obliquity and axial-dipolar geomagnetic field from evaporite palaeolatitudes.

Evans; (Journal Article)

Cancer biology: second step to retinal tumours.

Wallace; (Comment, News)

Complex zeolite structure solved by combining powder diffraction and electron microscopy.

Gramm, Baerlocher, McCusker, Warrender, Wright, Han, Hong, Liu, Ohsuna, Terasaki; (Journal Article)

Islam and science: ambition and neglect.

none; (News)

Drilling for nanotech gold.

none; (Journal Article)

Islam and Science: an Islamist revolution.

Masood; (News)

Inactivation of the p53 pathway in retinoblastoma.

Laurie, Donovan, Shih, Zhang, Mills, Fuller, Teunisse, Lam, Ramos, Mohan, Johnson, Wilson, Rodriguez-Galindo, Quarto, Francoz, Mendrysa, Guy, Marine, Jochemsen, Dyer; (Journal Article)

Geochemistry: Does U-Pb date Earth's core formation?; How well can Pb isotopes date core formation? (Reply).

Wood, Halliday; (JOURNAL ARTICLE)

Islam and Science: the data gap.

Butler; (News)

Key Collaborator.

none; (JOURNAL ARTICLE)

Islam and Science: the Islamic world.

Abbott, Cyranoski, Masood; (News)

Enforced altruism in insect societies.

Wenseleers, Ratnieks; (Journal Article)

Having faith.

Kruger, Konner; (JOURNAL ARTICLE)

Correction.

none; (JOURNAL ARTICLE)

Market watch.

Macilwain; (JOURNAL ARTICLE)

Islam and Science: oil rich, science poor.

Giles; (News)

Photonics: a cooling light breeze.

Karrai; (Comment, News)

No room for complacency on drug resistance in Africa.

Hastings, Lalloo, Khoo; (Comment, Letter)

Neurobiology: crossed circuits.

Schwartz; (Comment, News)

Self-cooling of a micromirror by radiation pressure.

Gigan, Böhm, Paternostro, Blaser, Langer, Hertzberg, Schwab, Bäuerle, Aspelmeyer, Zeilinger; (Journal Article)

Genomics: blueprints for partnerships.

Stahl, Davidson; (Comment, News)

The pork-barrel diet.

Lang; (JOURNAL ARTICLE)

Post-mating sexual selection increases lifetime fitness of polyandrous females in the wild.

Fisher, Double, Blomberg, Jennions, Cockburn; (Journal Article)

Sub-kelvin optical cooling of a micromechanical resonator.

Kleckner, Bouwmeester; (Journal Article)

Stand up and be quoted.

Van Noorden; (Journal Article)

NIH researchers fear ethics rules will hit recruitment.

none; (News)

XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome.

Rigaud, Fondanèche, Lambert, Pasquier, Mateo, Soulas, Galicier, Le Deist, Rieux-Laucat, Revy, Fischer, de Saint Basile, Latour; (Journal Article)

Physical chemistry: porous solids get organized.

van Santen; (News)

Making the paper: Eberhard Fetz.

none; (JOURNAL ARTICLE)

Search for alien signals stalls for want of cash.

none; (News)

A precise past.

none; (JOURNAL ARTICLE)

Ethiopian plan for Lucy tour splits museums.

Dalton; (News)

Sidelines.

none; (JOURNAL ARTICLE)

Science

Cell biology. Nuclear pore complex models gel.

Burke; (Comment, Journal Article)

Ecology. Global loss of biodiversity harming ocean bounty.

Stokstad; (Comment, News)

Genetics. Small RNAs reveal an activating side.

Garber; (News)

Salary survey. U.S. life scientists report rising salaries and high job satisfaction.

Austin; (Journal Article)

Probing the Chiroptical Response of a Single Molecule.

Hassey, Swain, Hammer, Venkataraman, Barnes; (JOURNAL ARTICLE)

Materials science. Japanese latecomer joins race to build a hard x-ray laser.

Normile; (News)

Giant ringlike radio structures around galaxy cluster Abell 3376.

Bagchi, Durret, Neto, Paul; (Journal Article)

Protrudin induces neurite formation by directional membrane trafficking.

Shirane, Nakayama; (Journal Article)

Wildlife conservation. On the brink.

Vogel; (News)

Research funding. Olympics-level costs upset plan to move U.K. biomedical institute.

Marshall; (News)

Materials science. Polymers in the pore.

Elbaum; (Comment, Journal Article)

Renewable hydrogen from nonvolatile fuels by reactive flash volatilization.

Salge, Dreyer, Dauenhauer, Schmidt; (Journal Article)

Climate change. An ambitious, centrist approach to global warming legislation.

Doniger, Herzog, Lashof; (Journal Article)

100 years and counting: prospects for defeating Alzheimer's disease.

Roberson, Mucke; (Journal Article)

Imaging the sublimation dynamics of colloidal crystallites.

Savage, Blair, Levine, Guyer, Dinsmore; (Journal Article)

Accelerated evolution of conserved noncoding sequences in humans.

Prabhakar, Noonan, Pääbo, Rubin; (Journal Article)

Astronomy. Radio traces of cosmic shock waves.

Ensslin; (Comment, Journal Article)

On the lack of women in academic science.

Smith; (Comment, Letter)

Avian influenza. New H5N1 strain emerges in southern China.

Normile; (News)

On the lack of women in academic science.

Roberts; (Comment, Letter)

Comment on "Rapid uplift of the Altiplano revealed through 13C-18O bonds in paleosol carbonates".

Sempere, Hartley, Roperch; (Comment, Journal Article)

Impacts of biodiversity loss on ocean ecosystem services.

Worm, Barbier, Beaumont, Duffy, Folke, Halpern, Jackson, Lotze, Micheli, Palumbi, Sala, Selkoe, Stachowicz, Watson; (Journal Article)

Ecology. A renaissance in the study of abundance.

McGill; (Comment, Journal Article)

A century of Alzheimer's disease.

Goedert, Spillantini; (Journal Article)

The polarity protein Par-3 directly interacts with p75NTR to regulate myelination.

Chan, Jolicoeur, Yamauchi, Elliott, Fawcett, Ng, Cayouette; (Journal Article)

FG-rich repeats of nuclear pore proteins form a three-dimensional meshwork with hydrogel-like properties.

Frey, Richter, Görlich; (Journal Article)

Phytoplankton and Cloudiness in the Southern Ocean.

Meskhidze, Nenes; (JOURNAL ARTICLE)

Materials science. Colloidal encounters: a matter of attraction.

Frenkel; (Comment, Journal Article)

Salary survey.

Kennedy; (Editorial)

Transgenic mice with a reduced core body temperature have an increased life span.

Conti, Sanchez-Alavez, Winsky-Sommerer, Morale, Lucero, Brownell, Fabre, Huitron-Resendiz, Henriksen, Zorrilla, de Lecea, Bartfai; (Journal Article)

Bioterrorism agents. U.S. panel wants security rules applied to genomes, not pathogens.

Bhattacharjee; (News)

AIDS research. Center puts hold on mangabey experiments.

Cohen; (News)

U.S. politics. Scientists look to Missouri to show the way on stem cells.

Kintisch; (News)

WNT and DKK Determine Hair Follicle Spacing Through a Reaction-Diffusion Mechanism.

Sick, Reinker, Timmer, Schlake; (JOURNAL ARTICLE)

Localization of Iron in Arabidopsis Seed Requires the Vacuolar Membrane Transporter VIT1.

Kim, Punshon, Lanzirotti, Li, Alonso, Ecker, Kaplan, Guerinot; (JOURNAL ARTICLE)

Conflict of interest. NIH rules rile scientists, survey finds.

Kaiser; (News)

Pattern formation and shape changes in self-oscillating polymer gels.

Yashin, Balazs; (Journal Article)

U.S. research policy. Congress cancels contentious program to bolster industry.

Kintisch; (News)

Wildlife conservation. The carnivore comeback.

Enserink, Vogel; (News)

NASA space science. Hubble gets a green light, with other missions on hold.

Lawler; (News)

Physics. Beyond the particle in the box.

Walldén; (Comment, Journal Article)

Where water is oxidized to dioxygen: structure of the photosynthetic Mn4Ca cluster.

Yano, Kern, Sauer, Latimer, Pushkar, Biesiadka, Loll, Saenger, Messinger, Zouni, Yachandra; (Journal Article)

Coherent electronic fringe structure in incommensurate silver-silicon quantum wells.

Speer, Tang, Miller, Chiang; (Journal Article)

Biomedicine. Life, the universe, and body temperature.

Saper; (Comment, Journal Article)

How protected are coral reefs?

Ricciardi; (Comment, Letter)

Nature Methods

Protein interaction screening by quantitative immunoprecipitation combined with knockdown (QUICK).

Selbach, Mann; (JOURNAL ARTICLE)

Direct observation of individual endogenous protein complexes in situ by proximity ligation.

Söderberg, Gullberg, Jarvius, Ridderstråle, Leuchowius, Jarvius, Wester, Hydbring, Bahram, Larsson, Landegren; (JOURNAL ARTICLE)

Monitoring regulated protein-protein interactions using split TEV.

Wehr, Laage, Bolz, Fischer, Grünewald, Scheek, Bach, Nave, Rossner; (JOURNAL ARTICLE)

Nature Biotechnology

Recombinant expression of selectively sulfated proteins in Escherichia coli.

Liu, Schultz; (Journal Article)

Nature Medicine

Molecular ablation of ventricular tachycardia after myocardial infarction.

Sasano, McDonald, Kikuchi, Donahue; (JOURNAL ARTICLE)

Identification of a hormonal basis for gallbladder filling.

Choi, Moschetta, Bookout, Peng, Umetani, Holmstrom, Suino-Powell, Xu, Richardson, Gerard, Mangelsdorf, Kliewer; (Journal Article)

A male contraceptive targeting germ cell adhesion.

Mruk, Wong, Silvestrini, Cheng; (Journal Article)

Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.

Cheng, Petraglia, Li, Thiyagarajan, Zhong, Wu, Liu, Maggirwar, Deane, Fernández, Larue, Griffin, Chopp, Zlokovic; (Journal Article)

Nature Genetics

R-spondin1 tips the balance in sex determination.

Capel; (Journal Article)

Genome-wide tagging for everyone.

Need, Goldstein; (Journal Article)

Natural selection on human microRNA binding sites inferred from SNP data.

Chen, Rajewsky; (JOURNAL ARTICLE)

DNA methylation profiling of human chromosomes 6, 20 and 22.

Eckhardt, Lewin, Cortese, Rakyan, Attwood, Burger, Burton, Cox, Davies, Down, Haefliger, Horton, Howe, Jackson, Kunde, Koenig, Liddle, Niblett, Otto, Pettett, Seemann, Thompson, West, Rogers, Olek, Berlin, Beck; (JOURNAL ARTICLE)

Buffering mitochondrial DNA variation.

Baughman, Mootha; (Journal Article)

Touching base.

none; (Journal Article)

Transcription in the loop.

Göndör, Ohlsson; (Journal Article)

Diversity of microRNAs in human and chimpanzee brain.

Berezikov, Thuemmler, van Laake, Kondova, Bontrop, Cuppen, Plasterk; (JOURNAL ARTICLE)

Human genetics in the Crescent City.

none; (Journal Article)

Comparison of a proteomic approach with a microarray-based approach to detect exons in the mouse genome.

Sheng, Wang, Dai, Jiang, Li, Ma, Li, Zeng, Wu; (JOURNAL ARTICLE)

Hereditary pancreatitis caused by triplication of the trypsinogen locus.

Le Maréchal, Masson, Chen, Morel, Ruszniewski, Levy, Férec; (JOURNAL ARTICLE)

Bone talk.

Schiavi; (Journal Article)

Contribution of consanguinuity to polygenic and multifactorial diseases.

Rudan, Campbell, Carothers, Hastie, Wright; (Journal Article)

Research highlights.

none; (Journal Article)

Molecular Medicine

Proteomics

SELDI-TOF MS analysis of the Cardiac Troponin I forms present in plasma from patients with myocardial infarction.

Peronnet, Becquart, Poirier, Cubizolles, Choquet-Kastylevsky, Jolivet-Reynaud; (JOURNAL ARTICLE)

Proteomic analysis of glutathione transferases from the liver fluke parasite, Fasciola hepatica.

Chemale, Morphew, Moxon, Morassuti, Lacourse, Barrett, Johnston, Brophy; (JOURNAL ARTICLE)

Detection in human saliva of different statherin and P-B fragments and derivatives.

Inzitari, Cabras, Rossetti, Fanali, Vitali, Pellegrini, Paludetti, Manni, Giardina, Messana, Castagnola; (JOURNAL ARTICLE)

Proteomic analysis of reporter genes for molecular imaging of transplanted embryonic stem cells.

Wu, Cao, Dutta, Xie, Kim, Chungfat, Gambhir, Mathewson, Connolly, Brown, Wang; (JOURNAL ARTICLE)

Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques.

Burré, Beckhaus, Schägger, Corvey, Hofmann, Karas, Zimmermann, Volknandt; (JOURNAL ARTICLE)

Human body fluid proteome analysis.

Hu, Loo, Wong; (JOURNAL ARTICLE)

Mass spectrometry-based proteomic analysis of the epitope-tag affinity purified protein complexes in eukaryotes.

Chang; (JOURNAL ARTICLE)

Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markers.

Khwaja, Nolen, Mendrinos, Lewis, Olson, Pohl, Van Meir, Ritchie, Brat; (JOURNAL ARTICLE)

Mass spectrometric genomic data mining: Novel insights into bioenergetic pathways in Chlamydomonas reinhardtii.

Allmer, Naumann, Markert, Zhang, Hippler; (JOURNAL ARTICLE)

Glycoproteome profiling of transforming growth factor-beta (TGFbeta) signaling: Nonglycosylated cell death-inducing DFF-like effector A inhibits TGFbeta1-dependent apoptosis.

Iwahana, Yakymovych, Dubrovska, Hellman, Souchelnytskyi; (JOURNAL ARTICLE)

Annotated regions of significance of SELDI-TOF-MS spectra for detecting protein biomarkers.

Seng Tan, Ploner, Quandt, Lehtiö, Pernemalm, Lewensohn, Pawitan; (JOURNAL ARTICLE)

Proteome analysis of maize pollen for allergy-relevant components.

Petersen, Dresselhaus, Grobe, Becker; (JOURNAL ARTICLE)

Nature Drug Discovery

BMC Bioinformatics

HybGFS: a hybrid method for genome-fingerprint scanning.

Shinoda, Yachie, Masuda, Sugiyama, Sugimoto, Soga, Tomita; (JOURNAL ARTICLE)

Application of Petri net based analysis techniques to signal transduction pathways.

Sackmann, Heiner, Koch; (JOURNAL ARTICLE)

Novel metaheuristic for parameter estimation in nonlinear dynamic biological systems.

Rodriguez-Fernandez, Egea, Banga; (JOURNAL ARTICLE)

RiboSubstrates: a web application addressing the cleavage specificities of ribozymes in designated genomes.

Lucier, Bergeron, Brière, Ouellette, Elela, Perreault; (Journal Article)

Mining expressed sequence tags identifies cancer markers of clinical interest.

Campagne, Skrabanek; (Journal Article)

Topological basis of signal integration in the transcriptional-regulatory network of the yeast, Saccharomyces cerevisiae.

Farkas, Wu, Chennubhotla, Bahar, Oltvai; (JOURNAL ARTICLE)

A statistical score for assessing the quality of multiple sequence alignments.

Ahola, Aittokallio, Vihinen, Uusipaikka; (JOURNAL ARTICLE)

Bioinformatics

Dependence network modeling for biomarker identification.

Qiu, Wang, Ray Liu, Hu, Wu; (JOURNAL ARTICLE)

Towards clustering of incomplete microarray data without the use of imputation.

Kim, Lee, Lee, Lee; (JOURNAL ARTICLE)

Estimating p-values in small microarray experiments.

Yang, Churchill; (JOURNAL ARTICLE)

OmicBrowse: a browser of multidimensional omics annotations.

Toyoda, Mochizuki, Player, Heida, Sakaki; (JOURNAL ARTICLE)

GECO - linear visualization for comparative genomics.

Kuenne, Ghai, Chakraborty, Hain; (JOURNAL ARTICLE)

Simple sequence repeats in organellar genomes of rice: frequency and distribution in genic and intergenic regions.

Rajendrakumar, Biswal, Balachandran, Srinivasarao, Sundaram; (JOURNAL ARTICLE)

Proc Natl Acad Sci U S A

A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal.

Müh, Hare, Duerkop, Schuster, Hanzelka, Heim, Olson, Greenberg; (Journal Article)

Sjogren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.

Oak, Deane, Kharas, Luo, Lane, Cantley, Fruman; (Journal Article)

Changing green leaf volatile biosynthesis in plants: An approach for improving plant resistance against both herbivores and pathogens.

Shiojiri, Kishimoto, Ozawa, Kugimiya, Urashimo, Arimura, Horiuchi, Nishioka, Matsui, Takabayashi; (Journal Article)

Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics.

Zheng, Tang, Tang, Kudlicka, Ohtsubo, Ma, Marth, Farquhar, Lehtonen; (Journal Article)

Hagfish and lancelet fibrillar collagens reveal that type II collagen-based cartilage evolved in stem vertebrates.

Zhang, Cohn; (Journal Article)

Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila.

Guan, Middlebrooks, Alexander, Wasserman; (Journal Article)

Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model.

Fan, Reneker, Obrenovich, Strauch, Cheng, Jarvis, Ortwerth, Monnier; (Journal Article)

A Ras-induced conformational switch in the Ras activator Son of sevenless.

Freedman, Sondermann, Friedland, Kortemme, Bar-Sagi, Marqusee, Kuriyan; (Journal Article)

The protective role of silicon in the Arabidopsis-powdery mildew pathosystem.

Fauteux, Chain, Belzile, Menzies, Bélanger; (JOURNAL ARTICLE)

Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes.

Chen, Osada, Santamaria-Babi, Kannagi; (Journal Article)

Use of polysialic acid in repair of the central nervous system.

El Maarouf, Petridis, Rutishauser; (Journal Article)

CLA-1 and its splicing variant CLA-2 mediate bacterial adhesion and cytosolic bacterial invasion in mammalian cells.

Vishnyakova, Kurlander, Bocharov, Baranova, Chen, Abu-Asab, Tsokos, Malide, Basso, Remaley, Csako, Eggerman, Patterson; (JOURNAL ARTICLE)

The dynamics of Machiavellian intelligence.

Gavrilets, Vose; (Journal Article)

Profile of F. Stuart Chapin III.

Downey; (Journal Article)

Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer.

Fang, Senes, Cristian, Degrado, Hochstrasser; (Journal Article)

Evaluating alternative hypotheses for the early evolution and diversification of ants.

Brady, Schultz, Fisher, Ward; (JOURNAL ARTICLE)

A pathogen-inducible endogenous siRNA in plant immunity.

Katiyar-Agarwal, Morgan, Dahlbeck, Borsani, Villegas, Zhu, Staskawicz, Jin; (JOURNAL ARTICLE)

Universal scaling for polymer chain scission in turbulence.

Vanapalli, Ceccio, Solomon; (Journal Article)

A gender- and sexual orientation-dependent spatial attentional effect of invisible images.

Jiang, Costello, Fang, Huang, He; (Journal Article)

{micro}O-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits.

Ekberg, Jayamanne, Vaughan, Aslan, Thomas, Mould, Drinkwater, Baker, Abrahamsen, Wood, Adams, Christie, Lewis; (Journal Article)

Emergence and predominance of an H5N1 influenza variant in China.

Smith, Fan, Wang, Li, Qin, Zhang, Vijaykrishna, Cheung, Huang, Rayner, Peiris, Chen, Webster, Guan; (Journal Article)

From the Cover: Structure of a heparin-dependent complex of Hedgehog and Ihog.

McLellan, Yao, Zheng, Geisbrecht, Ghirlando, Beachy, Leahy; (JOURNAL ARTICLE)

Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade.

Tang, Goldman; (Journal Article)

Nonspecific binding to structured RNA and preferential unwinding of an exposed helix by the CYT-19 protein, a DEAD-box RNA chaperone.

Tijerina, Bhaskaran, Russell; (Journal Article)

Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells.

Gadue, Huber, Paddison, Keller; (Journal Article)

A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas.

Lee, Gillies, Fox, Guillaudeu, Fréchet, Dy, Szoka; (Journal Article)

Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.

Anikeeva, Lebedeva, Clapp, Goldman, Dustin, Mattoussi, Sykulev; (Journal Article)

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.

Harrison, Ceol, Lu, Horvitz; (Journal Article)

Disulfide cross-linking indicates that FlgM-bound and free {sigma}28 adopt similar conformations.

Sorenson, Darst; (Journal Article)

Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning.

Lai, Xu, Westphal, Paterlini, Olivier, Pavlidis, Karayiorgou, Gogos; (Journal Article)

uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues.

Meng, Tripathy, Shete, Ashfaq, Saboorian, Haley, Frenkel, Euhus, Leitch, Osborne, Clifford, Perkins, Beitsch, Khan, Morrison, Herlyn, Terstappen, Lane, Wang, Uhr; (JOURNAL ARTICLE)

Photoprotection of human retinal pigment epithelium cells against blue light-induced apoptosis by melanin free radicals from Sepia officinalis.

Seagle, Gasyna, Mieler, Norris; (Journal Article)

Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor.

Lewis, Dinarello; (Journal Article)

From the Cover: Self-recognition in an Asian elephant.

Plotnik, de Waal, Reiss; (Journal Article)

Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions.

Crick, Jayaraman, Frieden, Wetzel, Pappu; (Journal Article)

Vaccine assembly from surface proteins of Staphylococcus aureus.

Stranger-Jones, Bae, Schneewind; (Journal Article)

A neuroinductive biomaterial based on dopamine.

Gao, Kim, Coe, Zern, Sheppard, Wang; (Journal Article)

Valence-sensitive neurons exhibit divergent functional profiles in gregarious and asocial species.

Goodson, Wang; (Journal Article)

Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid.

Johnson, Betts, Radeke, Hageman, Anderson, Johnson; (JOURNAL ARTICLE)

MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle.

Morosetti, Mirabella, Gliubizzi, Broccolini, De Angelis, Tagliafico, Sampaolesi, Gidaro, Papacci, Roncaglia, Rutella, Ferrari, Tonali, Ricci, Cossu; (Journal Article)

Cardiac myosin binding protein c phosphorylation is cardioprotective.

Sadayappan, Osinska, Klevitsky, Lorenz, Sargent, Molkentin, Seidman, Seidman, Robbins; (Journal Article)

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors.

Taly, Corringer, Grutter, de Carvalho, Karplus, Changeux; (Journal Article)

A surprising METamorphosis: Autism genetics finds a common functional variant.

State; (Journal Article)

Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase.

Crawford, Dancy, Hill, Udwary, Townsend; (Journal Article)

Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice.

Hu, Swerdlow, Duffy, Weinmann, Lee, Li; (Journal Article)

Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo.

Kennedy, Barabé, Patterson, Bayani, Squire, Barber, Dick; (Journal Article)

Day-to-day dynamics of experience-cortisol associations in a population-based sample of older adults.

Adam, Hawkley, Kudielka, Cacioppo; (Journal Article)

Cognitive cladistics and cultural override in Hominid spatial cognition.

Haun, Rapold, Call, Janzen, Levinson; (JOURNAL ARTICLE)

Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants.

Johnson-Schlitz, Engels; (Journal Article)

The role of platelet adhesion receptor GPIb{alpha} far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis.

Bergmeier, Piffath, Goerge, Cifuni, Ruggeri, Ware, Wagner; (Journal Article)

Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel {alpha}1C subunit.

Tiwari, Zhang, Heller, Abernethy, Soldatov; (Journal Article)

Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum.

Baba, Hayashi, Fujii, Mizushima, Watarai, Wakamori, Numaga, Mori, Iino, Hikida, Kurosaki; (Journal Article)

Photoreactivation of DNA by an Archaeal nucleoprotein Sso7d.

Tashiro, Wang, Sugiyama; (Journal Article)

Statistics of cellular signal transduction as a race to the nucleus by multiple random walkers in compartment/phosphorylation space.

Lu, Shen, Zong, Hasty, Wolynes; (Journal Article)

Endothelial cellular senescence is inhibited by nitric oxide: Implications in atherosclerosis associated with menopause and diabetes.

Hayashi, Matsui-Hirai, Miyazaki-Akita, Fukatsu, Funami, Ding, Kamalanathan, Hattori, Ignarro, Iguchi; (Journal Article)

From the Cover: Depression induces bone loss through stimulation of the sympathetic nervous system.

Yirmiya, Goshen, Bajayo, Kreisel, Feldman, Tam, Trembovler, Csernus, Shohami, Bab; (Journal Article)

A boost for hearing in mosquitoes.

Hoy; (Journal Article)

Combinatorial methods for small-molecule placement in computational enzyme design.

Lassila, Privett, Allen, Mayo; (Journal Article)

Genetic basis for natural variation in seed vitamin E levels in Arabidopsis thaliana.

Gilliland, Magallanes-Lundback, Hemming, Supplee, Koornneef, Bentsink, Dellapenna; (JOURNAL ARTICLE)

Unique characteristics of Xanthomonas oryzae pv. oryzae AvrXa21 and implications for plant innate immunity.

Lee, Han, Bartley, Ronald; (JOURNAL ARTICLE)

Cryptochrome-1-dependent execution of programmed cell death induced by singlet oxygen in Arabidopsis thaliana.

Danon, Sánchez Coll, Apel; (Journal Article)

Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features.

Batra, Shock, Prasad, Beard, Hou, Pedersen, Sayer, Yagi, Kumar, Jerina, Wilson; (JOURNAL ARTICLE)

Phase knowledge enables rational screens for protein crystallization.

Anderson, Hansen, Quake; (Journal Article)

Multiple pathways of selected gene amplification during adaptive mutation.

Kugelberg, Kofoid, Reams, Andersson, Roth; (JOURNAL ARTICLE)

Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development.

Cho, Kim, Song, Farrell, Eblaghie, Kim, Tickle, Jung; (JOURNAL ARTICLE)

NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death.

de Rivero Vaccari, Casey, Aleem, Park, Corriveau; (Journal Article)

From the Cover: An in vitro assay reveals a role for the diaphragm protein PV-1 in endothelial fenestra morphogenesis.

Ioannidou, Deinhardt, Miotla, Bradley, Cheung, Samuelsson, Ng, Shima; (Journal Article)

Activation of estrogen receptor {alpha} increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo.

Wang, Irwin, Brinton; (Journal Article)

Inaugural Article: Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels.

Huber, Schermer, Müller, Höhne, Bartram, Calixto, Hagmann, Reinhardt, Koos, Kunzelmann, Shirokova, Krautwurst, Harteneck, Simons, Pavenstädt, Kerjaschki, Thiele, Walz, Chalfie, Benzing; (JOURNAL ARTICLE)

A critical role for I{kappa}B kinase {alpha} in the development of human and mouse squamous cell carcinomas.

Liu, Park, Zhu, Bustos, Liu, Shen, Fischer, Hu; (JOURNAL ARTICLE)

The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases.

Ono, Kasamatsu, Oka, Moss; (Journal Article)

A backbone-based theory of protein folding.

Rose, Fleming, Banavar, Maritan; (Journal Article)

N Engl J Med

Adjuvant chemotherapy for breast cancer--30 years later.

Levine, Whelan; (Comment, Editorial)

Images in clinical medicine. Necrobiosis lipoidica diabeticorum.

Wake, Fang; (Case Reports, Journal Article)

The severe gout of Emperor Charles V.

Couper; (Biography, Comment, Historical Article, Letter)

Dystonia.

Müller; (Comment, Letter)

Case 24-2006: a woman with hypotension after an overdose of amlodipine.

Erickson; (Comment, Letter)

Heart failure with preserved ejection fraction.

Arias, Alonso-Fernández, García-Río; (Comment, Letter)

Left ventricular assist device and drug therapy for the reversal of heart failure.

Birks, Tansley, Hardy, George, Bowles, Burke, Banner, Khaghani, Yacoub; (Clinical Trial, Journal Article)

Case 24-2006: a woman with hypotension after an overdose of amlodipine.

Thompson, Bryant, Lu; (Comment, Letter)

Paying for performance--risks and recommendations.

Fisher; (Journal Article)

Retraction: Sudbø J et al. DNA content as a prognostic marker in patients with oral leukoplakia. N Engl J Med 2001;344:1270-8 and Sudbø J et al. The influence of resection and aneuploidy on mortality in oral leukoplakia. N Engl J Med 2004;350:1405-13.

Curfman, Morrissey, Drazen; (Retraction of Publication)

Pay for performance in commercial HMOs.

Rosenthal, Landon, Normand, Frank, Epstein; (Journal Article)

Voters and health care in the 2006 election.

Blendon, Altman; (Journal Article)

Public report cards--cardiac surgery and beyond.

Steinbrook; (Journal Article)

Treatment of periodontal disease and the risk of preterm birth.

Michalowicz, Hodges, DiAngelis, Lupo, Novak, Ferguson, Buchanan, Bofill, Papapanou, Mitchell, Matseoane, Tschida; (Journal Article, Multicenter Study, Randomized Controlled Trial)

Case 24-2006: a woman with hypotension after an overdose of amlodipine.

Aggarwal, Gupta; (Comment, Letter)

Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia.

Regula, Rupinski, Kraszewska, Polkowski, Pachlewski, Orlowska, Nowacki, Butruk; (Journal Article, Validation Studies)

Pay-for-performance programs in the United Kingdom.

Tahrani, Varughese, Macleod; (Comment, Letter)

Resistant or difficult-to-control hypertension.

Chandran; (Comment, Letter)

Images in clinical medicine. Progression of a pedunculated polyp.

Fu, Sano; (Case Reports, Journal Article)

Heart failure with preserved ejection fraction.

Ahmed, Fleg, Gheorghiade; (Comment, Letter)

Tracheal replacement with aortic allografts.

Wurtz, Porte, Conti, Desbordes, Copin, Azorin, Martinod, Marquette; (Case Reports, Letter)

Clinical practice. Management of hyperglycemia in the hospital setting.

Inzucchi; (Journal Article, Review)

Epirubicin and cyclophosphamide, methotrexate, and fluorouracil as adjuvant therapy for early breast cancer.

Poole, Earl, Hiller, Dunn, Bathers, Grieve, Spooner, Agrawal, Fernando, Brunt, O'Reilly, Crawford, Rea, Simmonds, Mansi, Stanley, Harvey, McAdam, Foster, Leonard, Twelves; (Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial)

Clinical problem-solving. The missing piece.

Robertson, Janssen, Saint, Weinberger; (Case Reports, Journal Article)

When the failing, end-stage heart is not end-stage.

Renlund, Kfoury; (Comment, Editorial)

Heart failure with preserved ejection fraction.

Kessler; (Comment, Letter)

Preterm birth and periodontal disease.

Goldenberg, Culhane; (Comment, Editorial)

J Natl Cancer Inst

Childhood cancer--treatment at a cost.

Ron; (Comment, Editorial)

Living well post-cancer: care planning for survivors.

Hede; (News)

Stat bite: Number of cancer survivors by site, 2003.

none; (Journal Article)

Statins, fibrates, and melanoma risk: a systematic review and meta-analysis.

Freeman, Drake, Heilig, Graber, McNealy, Schilling, Dellavalle; (Journal Article)

Detection of life-threatening prostate cancer with prostate-specific antigen velocity during a window of curability.

Carter, Ferrucci, Kettermann, Landis, Wright, Epstein, Trock, Metter; (Journal Article)

Effects of intravenously administered recombinant vesicular stomatitis virus (VSV(deltaM51)) on multifocal and invasive gliomas.

Lun, Senger, Alain, Oprea, Parato, Stojdl, Lichty, Power, Johnston, Hamilton, Parney, Bell, Forsyth; (Journal Article)

Re: Completion of therapy by Medicare patients with stage III colon cancer.

Gibbs, McLaughlin, Skinner, Jones, Hayes, Chapman, Johns, Lim, Faragher; (Comment, Letter)

Efficacy and antivascular effects of EphA2 reduction with an agonistic antibody in ovarian cancer.

Landen, Lu, Han, Coffman, Bruckheimer, Halder, Mangala, Merritt, Lin, Gao, Schmandt, Kamat, Li, Thaker, Gershenson, Parikh, Gallick, Kinch, Sood; (Journal Article)

Re: Response of a KIT-positive extra-abdominal fibromatosis to imatinib mesylate and KIT genetic analysis.

Tamborini, Negri, Miselli, Lagonigro, Pricl, Pilotti; (Comment, Letter)

Negative data from lung cancer trial may change practice guidelines, study designs.

McNeil; (News)

Prostate-specific antigen and prostate cancer prognosis.

Church; (Comment, Editorial)

Re-evaluating adjuvant breast cancer trials: assessing hormone receptor status by immunohistochemical versus extraction assays.

Regan, Viale, Mastropasqua, Maiorano, Golouh, Carbone, Brown, Suurküla, Langman, Mazzucchelli, Braye, Grigolato, Gelber, Castiglione-Gertsch, Price, Coates, Goldhirsch, Gusterson; (Journal Article)

Geriatric oncology aims for clinical trials.

Sinha; (News)

Are Bayes' days upon us? Statistical methods could change the conduct of clinical trials.

Beckman; (News)

New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

Neglia, Robison, Stovall, Liu, Packer, Hammond, Yasui, Kasper, Mertens, Donaldson, Meadows, Inskip; (Journal Article)

Lancet

Who will lead the Global Fund?

none; (Editorial)

Indirect comparisons: the mesh and mess of clinical trials.

Ioannidis; (Comment, Journal Article)

Initial highly-active antiretroviral therapy with a protease inhibitor versus a non-nucleoside reverse transcriptase inhibitor: discrepancies between direct and indirect meta-analyses.

Chou, Fu, Huffman, Korthuis; (Journal Article, Meta-Analysis, Review)

Where is maternal and child health now?

Lawn, Tinker, Munjanja, Cousens; (Journal Article, Review)

Renal replacement therapy in acute renal failure.

Schiffl, Lang; (Comment, Letter)

Effectiveness of pneumococcal conjugate vaccine.

O'Brien, Levine; (Comment, Journal Article)

Maternal health in poor countries: the broader context and a call for action.

Filippi, Ronsmans, Campbell, Graham, Mills, Borghi, Koblinsky, Osrin; (Journal Article, Review)

The food industry and health.

Martin; (Comment, Letter)

Lancet/Global Forum essay competition winners 2006.

Ramsay; (Journal Article)

WHO Director-General election.

O'Byrne; (Comment, Letter)

India's government aims to improve rural health.

Chatterjee; (News)

Mexican health reforms: global lessons, local solutions.

Horton; (Journal Article)

Renal replacement therapy in acute renal failure.

Chanard, Wynckel, Rieu; (Comment, Letter)

Scientific research in Iran: forgotten factors.

Habibzadeh, Vessal; (Comment, Letter)

Hilda Tadria: proponent of gender equality and maternal health.

Shetty; (Biography, Historical Article, News)

Health effects of Maoist insurgency in Nepal.

Ghimire, Pun; (Comment, Letter)

Yet another country infested with cluster bombs.

none; (Editorial)

An alternative strategy to reduce maternal mortality.

Costello, Azad, Barnett; (Journal Article)

Disappearance of immunoglobulins in acute phase of influenza A infection.

Logtenberg, Pasma, Wolfhagen, Dikkeschei, Bilo; (Case Reports, Journal Article)

Suicide in recently released prisoners.

Bird; (Comment, Letter)

Russia cracks down on counterfeit drugs.

Parfitt; (News)

9 years on: what progress has been made on achieving UK health-care equity?

Raine, McIvor; (Journal Article, Review)

Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study.

Whitney, Pilishvili, Farley, Schaffner, Craig, Lynfield, Nyquist, Gershman, Vazquez, Bennett, Reingold, Thomas, Glode, Zell, Jorgensen, Beall, Schuchat; (Journal Article)

Socioeconomic differentials in caesarean rates in developing countries: a retrospective analysis.

Ronsmans, Holtz, Stanton; (Journal Article)

The Lebanese crisis.

Goihman-Yahr; (Comment, Letter)

Essential reforms still elude the UK coroner system.

none; (Editorial)

Comprehensive reform to improve health system performance in Mexico.

Frenk, González-Pier, Gómez-Dantés, Lezana, Knaul; (Journal Article, Review)

Caesarean section: the paradox.

Althabe, Belizán; (Comment, Journal Article)

AIDS 2006 and beyond.

Cahn, McClure; (Comment, Letter)

Expert Rev Mol Diagn